Network News: The Replication of Kinetoplast DNA

被引：185

作者：

Jensen, Robert E. ^{[1
]}

Englund, Paul T. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 66 | 2012年 / 66卷

关键词：

trypanosomes; minicircle; maxicircle; kDNA replication; kDNA segregation; SEQUENCE-BINDING-PROTEIN; TRYPANOSOMA-BRUCEI KINETOPLAST; MITOCHONDRIAL-DNA; CRITHIDIA-FASCICULATA; CELL-CYCLE; MINICIRCLE REPLICATION; UNIVERSAL MINICIRCLE; AFRICAN TRYPANOSOMES; GENOME SEGREGATION; RNA INTERFERENCE;

D O I：

10.1146/annurev-micro-092611-150057

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One of the most fascinating and unusual features of trypanosomatids, parasites that cause disease in many tropical countries, is their mitochondrial DNA. This genome, known as kinetoplast DNA (kDNA), is organized as a single, massive DNA network formed of interlocked DNA rings. In this review, we discuss recent studies on kDNA structure and replication, emphasizing recent developments on replication enzymes, how the timing of kDNA synthesis is controlled during the cell cycle, and the machinery for segregating daughter networks after replication.

引用

页码：473 / 491

页数：19

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