The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia

被引：4
作者：
Stuge, Tor B. [1 ,2 ]
Skogen, Bjorn [1 ,2 ]
Ahlen, Maria Therese [1 ,2 ]
Husebekk, Anne [1 ,2 ]
Urbaniak, Stanislaw J. [3 ,4 ,5 ]
Bessos, Hagop [3 ,4 ]
机构：
[1] Univ Tromso, Inst Med Biol, Immunol Res Grp, Tromso, Norway
[2] Univ Hosp N Norway, Lab Med, Tromso, Norway
[3] Scottish Natl Blood Transfus Serv, Res & Dev Directorate, Edinburgh, Midlothian, Scotland
[4] Scottish Natl Blood Transfus Serv, Res & Dev Directorate, Aberdeen, Scotland
[5] Univ Aberdeen, Div Appl Med, Aberdeen AB9 1FX, Scotland
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2011年 / 45卷 / 01期
关键词：
Anti-HPA-1a antibodies; Pregnancy; Thrombocytopenia; FNAIT; MEMBRANE GLYCOPROTEIN IIIA; T-CELLS; PLACENTAL SYNCYTIOTROPHOBLAST; PLATELET GLYCOPROTEIN; MATERNAL CIRCULATION; ANTIGEN; POLYMORPHISM; IMMUNOTHERAPY; SPECIFICITY; REACTIVITY;
D O I：
10.1016/j.transci.2011.06.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that cross the placenta in connection with pregnancy and destroy fetal platelets. Recently, maternal T cell responses associated with FNAIT have been studied at the clonal level. These T cell clones recognize an integrin beta 3 epitope, which is anchored to the HLA-DRB3*0101-encoded MHC molecule DR52a. The same MHC allele is strongly associated with FNAIT. As the production of pathological antibodies reactive with fetal platelets is likely dependent on these T cell responses, there exists a potential for preventing FNAIT by targeting these T cells. (C) 2011 Published by Elsevier Ltd.
引用
收藏
页码：53 / 59
页数：7
相关论文
共 32 条
[1]   T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells [J].
Ahlen, Maria Therese ;
Husebekk, Anne ;
Killie, Mette Kjaer ;
Skogen, Bjorn ;
Stuge, Tor B. .
BLOOD, 2009, 113 (16) :3838-3844
[2]   Therapeutic manipulation of immune tolerance in allergic disease [J].
Akdis, Muebeccel ;
Akdis, Cezmi A. .
NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (08) :645-660
[3]   Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy [J].
Francis, JN ;
Till, SJ ;
Durham, SR .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (06) :1255-1261
[4]  
GORSKI J, 1986, NATURE, V322, P67, DOI 10.1038/322067a0
[5]   Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation [J].
Huppertz, B ;
Kingdom, J ;
Caniggia, I ;
Desoye, G ;
Black, S ;
Korr, H ;
Kaufmann, P .
PLACENTA, 2003, 24 (2-3) :181-190
[6]   INTEGRINS - VERSATILITY, MODULATION, AND SIGNALING IN CELL-ADHESION [J].
HYNES, RO .
CELL, 1992, 69 (01) :11-25
[7]   Reactivity of T cells from women with antibodies to the human platelet antigen (HPA)-1a to peptides encompassing the HPA-1 polymorphism [J].
Jackson, DJ ;
Murphy, MF ;
Soothill, PW ;
Lucas, GF ;
Elson, CJ ;
Kumpel, BM .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 142 (01) :92-102
[8]   A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn [J].
Killie, Mette Kjaer ;
Husebekk, Anne ;
Kjeldsen-Kragh, Jens ;
Skogen, Bjorn .
HAEMATOLOGICA, 2008, 93 (06) :870-877
[9]   A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia [J].
Kjeldsen-Kragh, Jens ;
Killie, Mette Kjaer ;
Tomter, Geir ;
Golebiowska, Elzbieta ;
Randen, Ingrid ;
Hauge, Reidun ;
Aune, Berit ;
Oian, Pal ;
Dahl, Lauritz B. ;
Pirhonen, Jouko ;
Lindeman, Rolf ;
Husby, Henrik ;
Haugen, Guttorm ;
Gronn, Morten ;
Skogen, Bjorn ;
Husebekk, Anne .
BLOOD, 2007, 110 (03) :833-839
[10]   New HLA haplotype frequency reference standards:: High-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans [J].
Klitz, W ;
Maiers, M ;
Spellman, S ;
Baxter-Lowe, LA ;
Schmeckpeper, B ;
Williams, TM ;
Fernandez-Viña, M .
TISSUE ANTIGENS, 2003, 62 (04) :296-307
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