Microsynthesis and gas chromatography/electron ionization mass spectrometric and tandem mass spectrometric analysis of cyclic alkylphosphonates for verification of the Chemical Weapons Convention

被引：5

作者：

Dubey, Devendra K. ^{[1
]}

Pardasani, Deepak ^{[1
]}

Kanaujia, Pankaj K. ^{[1
]}

Tak, Vijay ^{[1
]}

Gupta, Hernendra K. ^{[1
]}

机构：

[1] Def Res & Dev Estab, Vertox Lab, Gwalior 474002, India

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2008年 / 22卷 / 16期

关键词：

D O I：

10.1002/rcm.3644

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the microsynthesis and gas chromatography/mass spectrometric (GC/MS) analysis of cyclic alkylphosphonates (CAPs), which are included in schedule 2B4 chemicals in the Chemical Weapons Convention (CWC). The reported microsynthesis is efficient in comparison with traditional synthesis. GC/MS and GC/tandem mass spectrometric (MS/MS) analysis of a variety of CAPs revealed that their fragmentations were dominated by alpha-cleavages, alkene eliminations and hydrogen rearrangements. Based on the obtained mass spectra and precursor and product ion analysis of five-, six- and seven-membered cyclic alkylphosphonates, the proposed fragmentation routes rationalize most of the characteristic ions. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：2526 / 2532

页数：7

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