Insulin resistance and AD-extending the translational path

被引：98

作者：

Craft, Suzanne ^{[1
]}

机构：

[1] Vet Affairs Puget Sound, Geriatr Res Educ & Clin Ctr, Seattle, WA 98108 USA

来源：

NATURE REVIEWS NEUROLOGY | 2012年 / 8卷 / 07期

关键词：

TRANSGENIC MOUSE MODEL; ALZHEIMERS-DISEASE; AMYLOIDOSIS; OLIGOMERS; BRAIN;

D O I：

10.1038/nrneurol.2012.112

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two recent studies have carefully characterized amyloid-related brain insulin resistance in animal models of, and patients with, Alzheimer disease (AD). The researchers show that exendin-4, a glucagon-like peptide 1 receptor agonist, ameliorates pathology and symptoms in a mouse model of AD, suggesting a novel therapeutic approach to this disease.

引用

页码：360 / 362

页数：4

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