Role of cyclopentenone prostaglandins in rat carrageenin pleurisy

被引：46
作者：
Ianaro, A [1 ]
Ialenti, A [1 ]
Maffia, P [1 ]
Pisano, B [1 ]
Di Rosa, M [1 ]
机构：
[1] Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy
来源：
FEBS LETTERS | 2001年 / 508卷 / 01期
关键词：
carrageenin pleurisy; cyclooxygenase inhibitor; heat shock factor; heat shock protein; nuclear factor-kappa B; transcription factor;
D O I：
10.1016/S0014-5793(01)03035-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, using rat carrageenin-induced pleurisy, we found that treatment of rats with either indomethacin or NS398 suppressed the pleurisy at 2 h but significantly exacerbated this reaction at 48 h. Exacerbated inflammation was associated with reduced prostaglandin D-2 levels, decreased heat shock factor 1 (HSF1) activation, reduced hsp72 expression and increased activation of nuclear factor KB (NF-KB). Replacement of cyclopentenone prostaglandins by treating rats with either prostaglandin J(2) or prostaglandin D-2 reversed the exacerbating effects of cyclooxygenase inhibitors leading to the resolution of the reaction. In conclusion, we demonstrate that cyclopentenone prostaglandins may act as anti-inflammatory mediators by inducing in inflammatory cells HSF1-dependent hsp72 expression and NF-kappaB inhibition, two crucial events for the remission of inflammation. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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收藏
页码：61 / 66
页数：6
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