Ser-His catalyses the formation of peptides and PNAs

被引：69

作者：

Gorlero, Macha ^{[1
]}

Wieczorek, Rafal ^{[1
,2
]}

Adamala, Katarzyna ^{[3
]}

Giorgi, Alessandra ^{[4
]}

Schinina, Maria Eugenia ^{[4
,5
]}

Stano, Pasquale ^{[1
]}

Luisi, Pier Luigi ^{[1
]}

机构：

[1] Univ RomaTre, Dept Biol, Rome, Italy

[2] Univ Ca Foscari, European Ctr Living Technol, Venice, Italy

[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[4] Univ Roma La Sapienza, Dept Biochem Sci, I-00185 Rome, Italy

[5] Univ Roma La Sapienza, Lab Funct Genom & Prote Model Organisms, I-00185 Rome, Italy

来源：

FEBS LETTERS | 2009年 / 583卷 / 01期

关键词：

Organocatalysis; Peptide condensation; Fragment condensation; Origins of life; Prebiotic chemistry; PREBIOTIC CONDITIONS; HISTIDYL-HISTIDINE; BOND FORMATION; ACID; OLIGOPEPTIDES; GLYCINE; EVOLUTION; DNA;

D O I：

10.1016/j.febslet.2008.11.052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dipeptide seryl-histidine (Ser-His) catalyses the condensation of esters of amino acids, peptide fragments, and peptide nucleic acid (PNA) building blocks, bringing to the formation of peptide bonds. Di-, tri- or tetra-peptides can be formed with yields that vary from 0.5% to 60% depending on the nature of the substrate and on the conditions. Other simpler peptides as Gly-Gly, or Gly-Gly-Gly are also effective, although less efficiently. We discuss the results from the viewpoint of primitive chemistry and the origin of long macromolecules by stepwise fragment condensations. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：153 / 156

页数：4

共 25 条

[11] Dipeptide seryl-histidine and related oligopeptides cleave DNA, protein, and a carboxyl ester [J].