Influenza and the challenge for immunology

被引：287

作者：

Doherty, PC ^{[1
]}

Turner, SJ

Webby, RG

Thomas, PG

机构：

[1] Univ Melbourne, Sch Med, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

[2] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 05期

关键词：

D O I：

10.1038/ni1343

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality rate of humans infected with H5N1 are a source of great international concern. A mutant H5N1 virus with the capability to spread rapidly between humans could cause a global catastrophe. Governments have reacted by developing national response plans, stockpiling antiviral drugs and speeding up the development and approval of vaccines. Here we summarize what is known about the interaction between influenza A viruses and the mammalian host response, specifically emphasizing issues that might be of interest to the broader immunology community.

引用

页码：449 / 455

页数：7

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