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Enantioselective conjugate addition of 3-fluorooxindoles to vinyl sulfone: an organocatalytic access to chiral 3-fluoro-3-substituted oxindoles
被引:56
作者:
Dou, Xiaowei
Lu, Yixin
[1
]
机构:
[1] Natl Univ Singapore, Inst Life Sci, Dept Chem, Singapore 117543, Singapore
关键词:
ASYMMETRIC MICHAEL ADDITION;
N-FLUOROAMMONIUM SALTS;
3-SUBSTITUTED OXINDOLES;
MANNICH REACTION;
KETO ESTERS;
BMS-204352 MAXIPOST(TM);
PHOSPHINES SYNTHESIS;
CINCHONA ALKALOIDS;
CARBONYL-COMPOUNDS;
FACILE ACCESS;
D O I:
10.1039/c3ob41267a
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
An organocatalytic conjugate addition of prochiral 3-fluorinated oxindoles to vinyl sulfones was described for the first time. In the presence of bifunctional tertiary amine-thiourea catalysts, 3-fluoro-3-substituted oxindole adducts were obtained in excellent yields and with high enantiomeric excesses.
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页码:5217 / 5221
页数:5
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