A new, one-pot, multi-component synthesis of imines of 3-amino-2-arylimidazo[1,2-a]pyridines, 3-amino-2-arylimidazo[1,2-a]pyrazines, and 3-amino-2-arylimidazo[1,2-a]pyrimidines

被引：60

作者：

Abid, Mehdi ^{[1
]}

Sheibani, Esmail ^{[1
]}

Bijanzadeh, Hamid Reza ^{[2
]}

Zhu, Long-Guan ^{[3
]}

机构：

[1] Univ Tehran, Sch Chem, Univ Coll Sci, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[3] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

TETRAHEDRON | 2008年 / 64卷 / 47期

关键词：

2-Aminopyridines; 2-Aminopyrazine; 2-Aminopyrimidine; Benzaldehydes; Imidazoline-2,4,5-trione; 3-Amino-2-arylimidazo[1,2-a]pyridines; 3-Amino-2-arylimidazo[1,2-a]pyrazines; 3-Amino-2-arylimidazo[1,2-a]pyrimidines; Multi-component reactions;

D O I：

10.1016/j.tet.2008.09.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, one-pot, multi-component synthesis of 3-amino-2-arylmidazo[1,2-a]pyridines, 3-amino-2-arylimidazo[1,2-a]pyrazines, and 3-amino-2-arylimidazo[1,2-a]pyrimidines is described. Heating a Mixture of a 2-aminopyridine, 2-aminopyrazine or 2-aminopyrimidine, a benzaldehyde, and imidazoline-2,4,5-trione Under solvent-free conditions afforded imine derivatives of the title compounds in excellent yields. Single-crystal X-ray analysis conclusively confirms the structure of these bridgehead bicyclic 5-6 heterocycles. (C) 2008 Published by Elsevier Ltd.

引用

页码：10681 / 10686

页数：6