Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

被引：354

作者：

Neufer, P. Darrell ^{[1
,2
]}

Bamman, Marcas M. ^{[3
,4
]}

Muoio, Deborah M. ^{[5
]}

Bouchard, Claude ^{[6
]}

Cooper, Dan M. ^{[7
,8
]}

Goodpaster, Bret H. ^{[9
]}

Booth, Frank W. ^{[10
,11
,12
]}

Kohrt, Wendy M. ^{[13
]}

Gerszten, Robert E. ^{[14
,15
,16
]}

Mattson, Mark P. ^{[17
]}

Hepple, Russell T. ^{[18
]}

Kraus, William E. ^{[5
]}

Reid, Michael B. ^{[19
]}

Bodine, Sue C. ^{[20
]}

Jakicic, John M. ^{[21
]}

Fleg, Jerome L. ^{[22
]}

Williams, John P. ^{[23
]}

Joseph, Lyndon ^{[23
]}

Evans, Mary ^{[24
]}

Maruvada, Padma ^{[24
]}

Rodgers, Mary ^{[25
]}

Roary, Mary ^{[26
]}

Boyce, Amanda T. ^{[27
]}

Drugan, Jonelle K. ^{[27
]}

Koenig, James I. ^{[28
]}

Ingraham, Richard H. ^{[29
]}

Krotoski, Danuta ^{[30
]}

Garcia-Cazarin, Mary ^{[31
]}

McGowan, Joan A. ^{[27
]}

Laughlin, Maren R. ^{[24
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Physiol, East Carolina Diabet & Obes Inst, Greenville, NC 27834 USA

[2] E Carolina Univ, Brody Sch Med, Dept Kinesiol, East Carolina Diabet & Obes Inst, Greenville, NC 27834 USA

[3] Univ Alabama Birmingham, UAB Ctr Exercise Med, Birmingham, AL 35294 USA

[4] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA

[5] Duke Univ, Sch Med, Duke Mol Physiol, Durham, NC 27701 USA

[6] Louisiana State Univ, Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA

[7] Univ Calif Irvine, UC Irvine Inst Clin & Translat Sci, Irvine, CA 92697 USA

[8] Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA

[9] Florida Hosp, Sanford Burnham Med Res Inst, Translat Res Inst Metab & Diabet, Orlando, FL 32804 USA

[10] Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA

[11] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA

[12] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65211 USA

[13] Univ Colorado, Sch Med, Div Geriatr Med, Aurora, CO 80045 USA

[14] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[15] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

[16] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

[17] NIA, Lab Neurosci, Intramural Res Program, Baltimore, MD 21224 USA

[18] McGill Univ, Ctr Hlth, Dept Kinesiol, Montreal, PQ H2W 1S4, Canada

[19] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA

[20] Univ Calif Davis, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA

[21] Univ Pittsburgh, Dept Hlth & Phys Act, Phys Act & Weight Management Res Ctr, Pittsburgh, PA 15261 USA

[22] NHLBI, NIH, Bethesda, MD 20892 USA

[23] NIA, NIH, Bethesda, MD 20892 USA

[24] NIDDK, NIH, Bethesda, MD 20892 USA

[25] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD 20892 USA

[26] NINR, NIH, Bethesda, MD 20892 USA

[27] NIAMSD, NIH, Bethesda, MD 20892 USA

[28] Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD 20892 USA

[29] NIH, Ctr Sci Review, Bethesda, MD 20892 USA

[30] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA

[31] NIH, Off Dis Prevent, Bethesda, MD 20892 USA

来源：

CELL METABOLISM | 2015年 / 22卷 / 01期

关键词：

MESSENGER-RNA EXPRESSION; HUMAN SKELETAL-MUSCLE; MITOCHONDRIAL BIOGENESIS; RESISTANCE EXERCISE; MODERATE EXERCISE; GENE-EXPRESSION; RISK; RECOVERY; FITNESS; STRRIDE;

D O I：

10.1016/j.cmet.2015.05.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly understood. To identify major gaps in knowledge and potential strategies for catalyzing progress in the field, the NIH convened a workshop in late October 2014 entitled "Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.'' Presentations and discussions emphasized the challenges imposed by the integrative and intermittent nature of PA, the tremendous discovery potential of applying "-omics'' technologies to understand interorgan crosstalk and biological networking systems during PA, and the need to establish an infrastructure of clinical trial sites with sufficient expertise to incorporate mechanistic outcome measures into adequately sized human PA trials. Identification of the mechanisms that underlie the link between PA and improved health holds extraordinary promise for discovery of novel therapeutic targets and development of personalized exercise medicine.

引用

页码：4 / 11

页数：8

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