Cognitive Impairment in Studies of 5HTTLPR and Psychosis in Alzheimer's Disease: A Systematic Review

被引：8

作者：

Creese, Byron ^{[1
]}

Ballard, Clive ^{[1
]}

Jones, Emma ^{[1
]}

机构：

[1] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, England

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2013年 / 35卷 / 3-4期

关键词：

Cognition; SLC6A4; Dementia; Psychosis; Delusions; Hallucinations; PSYCHOLOGICAL SYMPTOMS; NEUROPSYCHIATRIC-SYMPTOMS; BEHAVIORAL DISTURBANCES; 5-HTTLPR POLYMORPHISM; PSYCHIATRIC-SYMPTOMS; DEMENTIA; RISK; ASSOCIATION; SEVERITY; SLC6A4;

D O I：

10.1159/000346733

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: Cognitive impairment is a well-established correlate of psychotic symptoms in Alzheimer's disease (AD-P). We review whether this relationship has confounded previous genetic association studies of 5HTTLPR and AD-P. Methods: We reviewed all studies on 5HTTLPR and conducted a semi-quantitative analysis. Results: Three out of 4 studies with low MMSE reported a significant association, while 1 out of 4 with high MMSE reported a significant association. Conclusions: Variation in cognitive impairment in past studies has contributed to the inconsistency in findings. The findings presented here bring a greater clarity to our understanding of the role of 5HTTLPR in AD-P. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：155 / 164

页数：10

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