Enhanced BDNF serum levels in patients with severe pathological gambling

被引：20
作者：
Angelucci, Francesco [1 ]
Martinotti, Giovanni [2 ]
Gelfo, Francesca [1 ]
Righino, Elisabetta [2 ]
Conte, Gianluigi [2 ]
Caltagirone, Carlo [1 ]
Bria, Pietro [2 ]
Ricci, Valerio [1 ,2 ]
机构：
[1] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, I-00179 Rome, Italy
[2] Catholic Univ, Inst Psychiat, Rome, Italy
来源：
ADDICTION BIOLOGY | 2013年 / 18卷 / 04期
关键词：
BDNF; dopamine; ELISA; pathological gambling; serum levels; SOGS; PROBLEM GAMBLERS; DISORDERS; REWARD; BRAIN;
D O I：
10.1111/j.1369-1600.2011.00411.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although the pathophysiology of gambling is unknown, an involvement of midbrain dopaminergic pathway has been hypothesized. In this study, the association between brain-derived neurotrophic factor (BDNF) and pathological gambling was investigated. We measured BDNF serum levels in (1) video players (n=10); (2) card players (n=9); (3) mixed players (n=21; both video and card players) and (4) age-matched controls (n=18). Mixed players had increased BDNF serum levels as compared to controls and higher South Oaks Gambling Screen score as compared to card or video players. Thus, the data demonstrate that patients affected by severe pathological gambling show enhanced BDNF serum levels.
引用
收藏
页码：749 / 751
页数：3
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