The Analysis of Association between Type 2 Diabetes and Polymorphic Markers in the CDKAL1 Gene and in the HHEX/IDE Locus

被引：2

作者：

Khodyrev, D. S. ^{[1
]}

Nikitin, A. G. ^{[1
]}

Brovkin, A. N. ^{[1
]}

Lavrikova, E. Yu. ^{[1
]}

Lebedeva, N. O. ^{[2
,4
]}

Vikulova, O. K. ^{[2
,4
]}

Shamhalova, M. Sh. ^{[2
,4
]}

Shestakova, M. V. ^{[2
,4
]}

Mayorov, M. Yu. ^{[2
,4
]}

Potapov, V. A. ^{[3
]}

Nosikov, V. V. ^{[1
]}

Averyanov, A. V. ^{[1
]}

机构：

[1] Fed Med & Biol Agcy Russia, Fed Res Clin Ctr, Moscow 115682, Russia

[2] Endocrinol Res Ctr, Dept Pediat, Moscow 117036, Russia

[3] Clin New Med Technol Archimedes, Moscow 129128, Russia

[4] Sechenov First Moscow State Med Univ, Dept Endocrinol & Diabetol, Moscow 119991, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2016年 / 52卷 / 11期

基金：

俄罗斯基础研究基金会; 俄罗斯科学基金会;

关键词：

type; 2; diabetes; insulin resistance; haplotype; CDKAL1; HHEX; IDE; GENOME-WIDE ASSOCIATION; INSULIN-DEGRADING ENZYME; PANCREATIC BETA-CELLS; COMMON VARIANTS; RISK LOCI; GLUCOSE; POPULATION; DEGRADATION; IGF2BP2; OVEREXPRESSION;

D O I：

10.1134/S1022795416110065

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The increase in diabetes was noted at the turn of the 21st century. Patients with type 2 diabetes (T2DM) make up the majority of patients. Diabetes is a multifactorial disease. It arises from adverse effects of environmental factors on the body of genetically susceptible peoples. According to modern concepts, T2DM is a polygenic disease. Each of the involved genes contributes to the risk of developing of this disease. In our study, the association between polymorphic genetic markers rs7756992, rs9465871, rs7754840, and rs10946398 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus and T2DM in the Russian population were studied. Four hundred forty patients with type 2 diabetes and 264 healthy individuals without any signs of the disease were examined. The comparative analysis of distribution of genotypes and allele frequencies points to an association between polymorphic genetic markers rs7756992, rs9465871, and rs10946398 in the CDKAL1 gene and this disease. For the other polymorphic genetic markers (rs7754840 in the CDKAL1 gene and rs1111875 in the HHEX/IDE locus), no statistically significant associations are found. On the basis of these data, we can conclude that the CDKAL1 gene is associated with development of T2DM. For the HHEX/IDE locus, such an association is absent.

引用

页码：1192 / 1199

页数：8

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