Antiproliferative Activity and Chemical Constituents of Hypericum dyeri. Rehder

被引：0

作者：

Ali, Mumtaz ^{[1
]}

Arfan, Mohammad ^{[2
]}

Zaman, Khair ^{[3
]}

Ahmad, Habib ^{[4
]}

Akbar, Nazia ^{[4
]}

Ahmed, Manzoor ^{[1
]}

Raza, Itrat ^{[5
]}

Shah, Raza ^{[6
]}

机构：

[1] Univ Malakand, Dept Chem, Chakdara, Pakistan

[2] Univ Peshawar, Inst Chem Sci, Peshawar, Pakistan

[3] Abdul Wali Khan Univ Mardan, Dept Chem, Mardan, Pakistan

[4] Hazara Univ, Dept Bot, Dudial, Mansehra, Pakistan

[5] Univ Karachi, Dept Chem, Karachi, Pakistan

[6] Univ Karachi, HEJ Res Inst Chem, ICCBS, Karachi 32, Pakistan

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2013年 / 35卷 / 02期

关键词：

Hypericum dyeri; Guttiferae; Antiproliferative; ANTIOXIDANT; EXTRACT;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The antiproliferative activity of hexane (F1), ethyl acetate (F2), butanol (F3) and water (F4) extracts of Hypericum dyeri were tested in vitro for their anti-proliferative (anticancer) activity on the cell lines: HT-29 human colon adenocarcinoma, NCI-H460 human non-small cell lung carcinoma, MCF-7 human breast cancer, OVCAR-3 human ovarian adenocarcinoma and RXF-393 human renal cell carcinoma with etoposide as positive control. Among the various extracts the F1 showed relatively potent anti-proliferative activity (IC50, 17.20 +/- 4.80 mu g/mL) on NCI-H460 human non-small cell lung carcinoma cell growth. Six compounds were also isolated for the first time from this source. These phytochemicals were identified as 1-Octatriacontanol (1), Hexacosyl tetracosanoate (2), Geddic acid (3), Octacosanoic acid (4), Ceric acid (5) and beta-Sitosterol (6) on the basis of spectroscopic studies such as H-1 NMR,C-13 NMR, 2D NMR and Mass spectroscopy as well as established with help of reported literature.

引用

页码：391 / 395

页数：5

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