The National Institute for Health and Clinical Excellence recently published a clinical guideline on the management of venous thromboembolic disease and thrombophilia testing. Several stand-out recommendations are made which may be practice changing for many physicians, such as catheter-directed thrombolysis for ilio-femoral deep venous thrombosis, routine cancer screening and extended duration of anticoagulation for unprovoked events. In this article, we summarise the key points of the guideline and discuss remaining areas of controversy.
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City Gen Univ Hosp N Staffordshire, Dept Resp Med, Stoke On Trent ST4 6QG, Staffs, EnglandCity Gen Univ Hosp N Staffordshire, Dept Resp Med, Stoke On Trent ST4 6QG, Staffs, England
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McMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
McMaster Univ, Dept Med, Fac Hlth Sci, Hamilton, ON L8N 3Z5, CanadaMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
Guyatt, Gordon H.
Akl, Elie A.
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McMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
SUNY Buffalo, Dept Med, Buffalo, NY 14260 USA
SUNY Buffalo, Dept Family Med, Buffalo, NY 14260 USAMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
Akl, Elie A.
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Crowther, Mark
Gutterman, David D.
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Med Coll Wisconsin, Cardiovasc Res Ctr, Milwaukee, WI 53226 USAMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
Gutterman, David D.
Schuenemann, Holger J.
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McMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
McMaster Univ, Dept Med, Fac Hlth Sci, Hamilton, ON L8N 3Z5, CanadaMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
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Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA
Washington Univ, Sch Med, Div Gen Med Sci, St Louis, MO USAHosp Ramon & Cajal, Resp Dept, IRYCIS, E-28034 Madrid, Spain
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McMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
McMaster Univ, Dept Clin Epidemiol & Biostat, Michael De Groote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Kearon, Clive
Akl, Elie A.
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SUNY Buffalo, Dept Med, Buffalo, NY 14260 USA
SUNY Buffalo, Dept Family Med, Buffalo, NY 14260 USA
SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Akl, Elie A.
Comerota, Anthony J.
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Jobst Vasc Ctr, Dept Surg, Toledo, OH USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Comerota, Anthony J.
Prandoni, Paolo
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Univ Padua, Dept Cardiothorac & Vasc Sci, Padua, ItalyMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Prandoni, Paolo
Bounameaux, Henri
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Univ Hosp Geneva, Dept Med Specialties, Geneva, SwitzerlandMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Bounameaux, Henri
Goldhaber, Samuel Z.
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Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Goldhaber, Samuel Z.
Nelson, Michael E.
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Shawnee Mission Med Ctr, Dept Med, Shawnee Mission, KS USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Nelson, Michael E.
Wells, Philip S.
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Univ Ottawa, Dept Med, Ottawa, ON, CanadaMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Wells, Philip S.
Gould, Michael K.
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Univ So Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Gould, Michael K.
Dentali, Francesco
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Univ Insubria, Dept Med, Varese, ItalyMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Dentali, Francesco
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Crowther, Mark
Kahn, Susan R.
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McGill Univ, Dept Med, Montreal, PQ, Canada
McGill Univ, Dept Clin Epidemiol & Biostat, Montreal, PQ, CanadaMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
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City Gen Univ Hosp N Staffordshire, Dept Resp Med, Stoke On Trent ST4 6QG, Staffs, EnglandCity Gen Univ Hosp N Staffordshire, Dept Resp Med, Stoke On Trent ST4 6QG, Staffs, England
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McMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
McMaster Univ, Dept Med, Fac Hlth Sci, Hamilton, ON L8N 3Z5, CanadaMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
Guyatt, Gordon H.
Akl, Elie A.
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机构:
McMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
SUNY Buffalo, Dept Med, Buffalo, NY 14260 USA
SUNY Buffalo, Dept Family Med, Buffalo, NY 14260 USAMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
Akl, Elie A.
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Crowther, Mark
Gutterman, David D.
论文数: 0引用数: 0
h-index: 0
机构:
Med Coll Wisconsin, Cardiovasc Res Ctr, Milwaukee, WI 53226 USAMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
Gutterman, David D.
Schuenemann, Holger J.
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h-index: 0
机构:
McMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
McMaster Univ, Dept Med, Fac Hlth Sci, Hamilton, ON L8N 3Z5, CanadaMcMaster Univ, Dept Clin Epidemiol & Biostat, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada
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Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA
Washington Univ, Sch Med, Div Gen Med Sci, St Louis, MO USAHosp Ramon & Cajal, Resp Dept, IRYCIS, E-28034 Madrid, Spain
机构:
McMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
McMaster Univ, Dept Clin Epidemiol & Biostat, Michael De Groote Sch Med, Hamilton, ON, CanadaMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Kearon, Clive
Akl, Elie A.
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Buffalo, Dept Med, Buffalo, NY 14260 USA
SUNY Buffalo, Dept Family Med, Buffalo, NY 14260 USA
SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Akl, Elie A.
Comerota, Anthony J.
论文数: 0引用数: 0
h-index: 0
机构:
Jobst Vasc Ctr, Dept Surg, Toledo, OH USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Comerota, Anthony J.
Prandoni, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Padua, Dept Cardiothorac & Vasc Sci, Padua, ItalyMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Prandoni, Paolo
Bounameaux, Henri
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Geneva, Dept Med Specialties, Geneva, SwitzerlandMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Bounameaux, Henri
Goldhaber, Samuel Z.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Goldhaber, Samuel Z.
Nelson, Michael E.
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h-index: 0
机构:
Shawnee Mission Med Ctr, Dept Med, Shawnee Mission, KS USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Nelson, Michael E.
Wells, Philip S.
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h-index: 0
机构:
Univ Ottawa, Dept Med, Ottawa, ON, CanadaMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Wells, Philip S.
Gould, Michael K.
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h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USAMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Gould, Michael K.
Dentali, Francesco
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h-index: 0
机构:
Univ Insubria, Dept Med, Varese, ItalyMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada
Dentali, Francesco
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Crowther, Mark
Kahn, Susan R.
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h-index: 0
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McGill Univ, Dept Med, Montreal, PQ, Canada
McGill Univ, Dept Clin Epidemiol & Biostat, Montreal, PQ, CanadaMcMaster Univ, Dept Med, Michael De Groote Sch Med, Hamilton, ON, Canada