Steroid-dependent minimal-change nephrotic syndrome (MCNS) requires administration of prolonged courses of prednisolone (PSL); therefore, a paradigm shift from such toxic non-specific therapies to selective immunomodulating regimens is necessary for these cases. To assess the therapeutic effects of rituximab (an anti-CD20 antibody) in adult patients with steroid-dependent MCNS, we performed a prospective trial of the effects of a single dose of rituximab administered twice at an interval of 6 months in 25 MCNS patients. We evaluated the biochemical parameters and compared the clinical findings between the 12-month period before and 12-month period after the first rituximab infusion. A significant reduction in the number of relapses and the total dose and the maintenance dose of PSL administered was observed during the 12-month period after the first rituximab infusion when compared with the findings during the 12-month period before the first rituximab infusion [25 (100) versus 4 (16), P 0.001; 8.2 versus 3.3 g, P 0.001; 26.4 mg/day at baseline versus 1.1 mg/day at 12-month, P 0.0001]. Complete remission was achieved/maintained in all patients undergoing B-cell depletion. Four of 17 patients with B-cell repletion developed relapse. Our results revealed that rituximab therapy was associated with a reduction in the number of relapses and in the total dose of PSL needed. Therefore, rituximab appears to be a useful therapeutic agent for adult patients with steroid-dependent MCNS. These results suggest that this treatment is rational and should be considered as an important option in the management of adult patients with steroid-dependent MCNS.
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Amemiya, Nobuyuki
;
Takei, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Takei, Takashi
;
Kojima, Chiari
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Kojima, Chiari
;
Nokiba, Hirohiko
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Nokiba, Hirohiko
;
Itabashi, Mitsuyo
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Itabashi, Mitsuyo
;
Nitta, Kosaku
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
机构:
Hop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Guigonis, Vincent
;
Dallocchio, Aymeric
论文数: 0引用数: 0
h-index: 0
机构:
Hop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Dallocchio, Aymeric
;
Baudouin, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Hop Robert Debre, AP HP, F-75019 Paris, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Baudouin, Veronique
;
Dehennault, Maud
论文数: 0引用数: 0
h-index: 0
机构:
Hop Jeanne Flanders, Lille, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Dehennault, Maud
;
Camus, Caroline Hachon-Le
论文数: 0引用数: 0
h-index: 0
机构:
Hop Purpan, Ctr Reference Malad Renales Rares Sud Ouest, Toulouse, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Camus, Caroline Hachon-Le
;
Afanetti, Mickael
论文数: 0引用数: 0
h-index: 0
机构:
Hop Archet 2, Nice, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Afanetti, Mickael
;
Groothoff, Jaap
论文数: 0引用数: 0
h-index: 0
机构:
Emma Childrens Hosp, Amsterdam, NetherlandsHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Groothoff, Jaap
;
Llanas, Brigitte
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pellegrin, Ctr Reference Malad Renales Rares Sud Ouest, F-33076 Bordeaux, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Llanas, Brigitte
;
Niaudet, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Hop Necker Enfants Malad, AP HP, Paris, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Niaudet, Patrick
;
Nivet, Hubert
论文数: 0引用数: 0
h-index: 0
机构:
Hop Clocheville, Tours, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Nivet, Hubert
;
Raynaud, Natacha
论文数: 0引用数: 0
h-index: 0
机构:
Hop F Guyon, La Reunion, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Raynaud, Natacha
;
Taque, Sophie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pontchaillou, Rennes, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Taque, Sophie
;
Ronco, Pierre
论文数: 0引用数: 0
h-index: 0
机构:
UPMC Univ Paris 06, Hop Tenon, AP HP, INSERM,UMR S 702,Dept Nephrol, F-75020 Paris, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Ronco, Pierre
;
Bouissou, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Hop Purpan, Ctr Reference Malad Renales Rares Sud Ouest, Toulouse, France
Ctr Reference Malad Revales Rares Sud Quest, Toulouse, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Amemiya, Nobuyuki
;
Takei, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Takei, Takashi
;
Kojima, Chiari
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Kojima, Chiari
;
Nokiba, Hirohiko
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Nokiba, Hirohiko
;
Itabashi, Mitsuyo
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
Itabashi, Mitsuyo
;
Nitta, Kosaku
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
机构:
Hop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Guigonis, Vincent
;
Dallocchio, Aymeric
论文数: 0引用数: 0
h-index: 0
机构:
Hop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Dallocchio, Aymeric
;
Baudouin, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Hop Robert Debre, AP HP, F-75019 Paris, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Baudouin, Veronique
;
Dehennault, Maud
论文数: 0引用数: 0
h-index: 0
机构:
Hop Jeanne Flanders, Lille, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Dehennault, Maud
;
Camus, Caroline Hachon-Le
论文数: 0引用数: 0
h-index: 0
机构:
Hop Purpan, Ctr Reference Malad Renales Rares Sud Ouest, Toulouse, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Camus, Caroline Hachon-Le
;
Afanetti, Mickael
论文数: 0引用数: 0
h-index: 0
机构:
Hop Archet 2, Nice, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Afanetti, Mickael
;
Groothoff, Jaap
论文数: 0引用数: 0
h-index: 0
机构:
Emma Childrens Hosp, Amsterdam, NetherlandsHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Groothoff, Jaap
;
Llanas, Brigitte
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pellegrin, Ctr Reference Malad Renales Rares Sud Ouest, F-33076 Bordeaux, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Llanas, Brigitte
;
Niaudet, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Hop Necker Enfants Malad, AP HP, Paris, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Niaudet, Patrick
;
Nivet, Hubert
论文数: 0引用数: 0
h-index: 0
机构:
Hop Clocheville, Tours, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Nivet, Hubert
;
Raynaud, Natacha
论文数: 0引用数: 0
h-index: 0
机构:
Hop F Guyon, La Reunion, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Raynaud, Natacha
;
Taque, Sophie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pontchaillou, Rennes, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Taque, Sophie
;
Ronco, Pierre
论文数: 0引用数: 0
h-index: 0
机构:
UPMC Univ Paris 06, Hop Tenon, AP HP, INSERM,UMR S 702,Dept Nephrol, F-75020 Paris, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France
Ronco, Pierre
;
Bouissou, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Hop Purpan, Ctr Reference Malad Renales Rares Sud Ouest, Toulouse, France
Ctr Reference Malad Revales Rares Sud Quest, Toulouse, FranceHop Mere & Enfant, Ctr Reference Malad Renales Rares Sud Ouest, Dept Pediat, F-87000 Limoges, France