Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

被引：49

作者：

Wen, Qiaodong ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 84期

关键词：

INTRAMOLECULAR PROTON-TRANSFER; ONE-POT SYNTHESIS; BETA-KETO-ESTERS; MULTICOMPONENT REACTION; ANTIVIRAL ACTIVITY; DIRECT ACCESS; 2-AMINOPYRIDINES; IMIDAZOPYRIDINES; CYCLIZATION; CYANATION;

D O I：

10.1039/c5cc05821j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, aceto-phenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.

引用

页码：15378 / 15381

页数：4

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