Endometriosis and Stem Cell Trafficking

被引：51

作者：

Pluchino, Nicola ^{[1
]}

Taylor, Hugh S. ^{[1
]}

机构：

[1] Yale Sch Med, Dept Obstet Gynecol & Reprod Sci, 333 Cedar St, New Haven, CT 06520 USA

来源：

REPRODUCTIVE SCIENCES | 2016年 / 23卷 / 12期

关键词：

endometriosis; stem cells; cell trafficking; endometrium; PARKINSONS-DISEASE; STROMAL CELLS; EXPRESSION; TRANSPLANTATION; ENGRAFTMENT; MIGRATION; CXCR4; MODEL;

D O I：

10.1177/1933719116671219

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Adult stem cells have a major role in endometrial physiology, remodeling, and repair, but they also have a critical role in the development and progression of endometriosis. Bone marrow-derived stem cells (BMDSCs) engraft eutopic endometrium and endometriotic lesions, showing stromal and epithelial fate. Nevertheless, circulating BMDSCs are in limited supply, and the presence of endometriosis depletes stem cells from the blood circulation, preventing their homing in the uterus. Furthermore, stem cells migrate from endometriotic lesion into the uterus, leading to a dysfunctional endometrium. Stem cell trafficking is a central feature of endometriosis. Understanding molecular mechanisms regulating cell mobility and engraftment in endometriosis may reveal new targets for treatment.

引用

页码：1616 / 1619

页数：4

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