Circulating tumor cells as an emerging tool in cancer therapy

被引：11

作者：

Balakrishnan, Ajay ^{[1
,2
]}

George, Irene A. ^{[1
]}

Kumar, Prashant ^{[1
,2
]}

机构：

[1] Inst Bioinformat, Discoverer Bldg,Int Technol Pk, Bangalore 560066, Karnataka, India

[2] Manipal Acad Higher Educ MAHE, Manipal 576104, Karnataka, India

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷

关键词：

Circulating tumor cells; CTC; CTC clusters; CTC culture; CTC derived explants; Review; NATURAL-KILLER-CELLS; IN-VIVO ISOLATION; LUNG-CANCER; MOLECULAR CHARACTERIZATION; PERIPHERAL-BLOOD; CLINICAL-SIGNIFICANCE; COLORECTAL-CANCER; PROGRESSION-FREE; DRUG-RESISTANCE; PROSTATE-CANCER;

D O I：

10.2741/4824

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Majority of the cancer-related deaths are related to metastasis during which cancer cells invade the surrounding tissues, enter (intravasation) and exit (extravasation) the peripheral circulation and seed distant organs. The Circulating Tumor Cells (CTCs) exist in peripheral blood as single cells or as oligoclonal clusters of tumor cells along with platelets and lymphocytes. Detection of CTCs allows characterizing the tumors by their genotype and in predicting the prognosis and response to therapy and explants derived from these cells can be used in drug screening. In this review, we highlight the methods used for isolation and culture of CTCs and their clinical use.

引用

页码：606 / 631

页数：26

共 141 条

[1] En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition [J].

Aceto, Nicola ;

Toner, Mehmet ;

Maheswaran, Shyamala ;

Haber, Daniel A. .

TRENDS IN CANCER, 2015, 1 (01) :44-52

[2] Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[3] Separation of adult bone marrow mononuclear cells using the automated closed separation system Sepax [J].

Aktas, M. ;

Radke, T. F. ;

Strauer, B. E. ;

Wernet, P. ;

Kogler, G. .

CYTOTHERAPY, 2008, 10 (02) :203-211

[4] Initiation and Characterization of Small Cell Lung Cancer Patient-Derived Xenografts from Ultrasound-Guided Transbronchial Needle Aspirates [J].

Anderson, Wade C. ;

Boyd, Michael B. ;

Aguilar, Jorge ;

Pickell, Brett ;

Laysang, Amy ;

Pysz, Marybeth A. ;

Bheddah, Sheila ;

Ramoth, Johanna ;

Slingerland, Brian C. ;

Dylla, Scott J. ;

Rubio, Edmundo R. .

PLOS ONE, 2015, 10 (05)

[5] Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect™ versus Veridex CellSearch™ system [J].

Andreopoulou, E. ;

Yang, L. -Y. ;

Rangel, K. M. ;

Reuben, J. M. ;

Hsu, L. ;

Krishnamurthy, S. ;

Valero, V. ;

Fritsche, H. A. ;

Cristofanilli, M. .

INTERNATIONAL JOURNAL OF CANCER, 2012, 130 (07) :1590-1597

[6]

[Anonymous], J PERIANESTH NURS

[7]

[Anonymous], 2018, Appl. Cancer Res, DOI DOI 10.1186/S41241-018-0059-7

[8]

ASSOIAN RK, 1983, J BIOL CHEM, V258, P7155

[9] Clusters of circulating tumor cells traverse capillary-sized vessels [J].

Au, Sam H. ;

Storey, Brian D. ;

Moore, John C. ;

Tang, Qin ;

Chen, Yeng-Long ;

Javaid, Sarah ;

Sarioglu, A. Fatih ;

Sullivan, Ryan ;

Madden, Marissa W. ;

O'Keefe, Ryan ;

Haber, Daniel A. ;

Maheswaran, Shyamala ;

Langenau, David M. ;

Stott, Shannon L. ;

Toner, Mehmet .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (18) :4947-4952

[10] Comprehensive Characterization of Cancer Driver Genes and Mutations (vol 173, 371.e1, 2018) [J].

Bailey, Matthew H. ;

Tokheim, Collin ;

Porta-Pardo, Eduard ;

Sengupta, Sohini ;

Bertrand, Denis ;

Weerasinghe, Amila ;

Colaprico, Antonio ;

Wendl, Michael C. ;

Kim, Jaegil ;

Reardon, Brendan ;

Ng, Patrick Kwok-Shing ;

Jeong, Kang Jin ;

Cao, Song ;

Wang, Zixing ;

Gao, Jianjiong ;

Gao, Qingsong ;

Wang, Fang ;

Liu, Eric Minwei ;

Mularoni, Loris ;

Rubio-Perez, Carlota ;

Nagarajan, Niranjan ;

Cortes-Ciriano, Isidro ;

Zhou, Daniel Cui ;

Liang, Wen-Wei ;

Hess, Julian M. ;

Yellapantula, Venkata D. ;

Tamborero, David ;

Gonzalez-Perez, Abel ;

Suphavilai, Chayaporn ;

Ko, Jia Yu ;

Khurana, Ekta ;

Park, Peter J. ;

Van Allen, Eliezer M. ;

Liang, Han ;

Lawrence, Michael S. ;

Godzik, Adam ;

Lopez-Bigas, Nuria ;

Stuart, Josh ;

Wheeler, David ;

Getz, Gad ;

Chen, Ken ;

Lazar, Alexander J. ;

Mills, Gordon B. ;

Karchin, Rachel ;

Ding, Li .

CELL, 2018, 174 (04) :1034-1035

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