Enemy or partner: Relationship between intronic micrornas and their host genes

被引：53

作者：

Gao, Xu ^{[1
]}

Qiao, Yu ^{[1
]}

Han, Dong ^{[1
]}

Zhang, Yanfen ^{[2
]}

Ma, Ning ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Biochem & Mol Biol, Harbin, Peoples R China

[2] Harbin Med Univ, Dept Lab Diag, Clin Med Coll 1, Harbin, Peoples R China

来源：

IUBMB LIFE | 2012年 / 64卷 / 10期

关键词：

intronic microRNA; host gene; antagonistic; synergetic; coexpression; INTRAGENIC MIRNAS; EXPRESSION; BIOGENESIS; MODULATE; TRANSLATION; COOPERATE; MECHANISM; MIR-675; EGFL7; RNA;

D O I：

10.1002/iub.1079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past several years, microRNAs have been identified as a class of important regulators of gene expression. One hot topic in the microRNA field is the location of microRNA genes. Most microRNAs are called intronic microRNAs, which are encoded in the introns of coding or non-coding genes. Some research studies have shown that intronic miRNAs coexpress and act similarly to their host genes; however, other research studies have suggested that their level of expression and function are opposite to that of their host genes. Intronic microRNAs have been reported to play an antagonistic or synergetic role as an enemy or a partner of their host genes. Elucidation of the relationship between intronic microRNAs and their host genes will facilitate a deeper understanding of gene expression and the function of introns. This mini review will discuss recent research addressing intronic microRNAs and their host genes. (c) 2012 IUBMB IUBMB Life, 64(10): 835840, 2012

引用

页码：835 / 840

页数：6

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