Enemy or partner: Relationship between intronic micrornas and their host genes

被引：52
作者：
Gao, Xu [1 ]
Qiao, Yu [1 ]
Han, Dong [1 ]
Zhang, Yanfen [2 ]
Ma, Ning [1 ]
机构：
[1] Harbin Med Univ, Dept Biochem & Mol Biol, Harbin, Peoples R China
[2] Harbin Med Univ, Dept Lab Diag, Clin Med Coll 1, Harbin, Peoples R China
来源：
IUBMB LIFE | 2012年 / 64卷 / 10期
关键词：
intronic microRNA; host gene; antagonistic; synergetic; coexpression; INTRAGENIC MIRNAS; EXPRESSION; BIOGENESIS; MODULATE; TRANSLATION; COOPERATE; MECHANISM; MIR-675; EGFL7; RNA;
D O I：
10.1002/iub.1079
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the past several years, microRNAs have been identified as a class of important regulators of gene expression. One hot topic in the microRNA field is the location of microRNA genes. Most microRNAs are called intronic microRNAs, which are encoded in the introns of coding or non-coding genes. Some research studies have shown that intronic miRNAs coexpress and act similarly to their host genes; however, other research studies have suggested that their level of expression and function are opposite to that of their host genes. Intronic microRNAs have been reported to play an antagonistic or synergetic role as an enemy or a partner of their host genes. Elucidation of the relationship between intronic microRNAs and their host genes will facilitate a deeper understanding of gene expression and the function of introns. This mini review will discuss recent research addressing intronic microRNAs and their host genes. (c) 2012 IUBMB IUBMB Life, 64(10): 835840, 2012
引用
收藏
页码：835 / 840
页数：6
相关论文
共 56 条
[1]   An intronic microRNA silences genes that are functionally antagonistic to its host gene [J].
Barik, Sailen .
NUCLEIC ACIDS RESEARCH, 2008, 36 (16) :5232-5241
[2]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[3]   Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes [J].
Baskerville, S ;
Bartel, DP .
RNA, 2005, 11 (03) :241-247
[4]   Uncoupling of Expression of an Intronic MicroRNA and Its Myosin Host Gene by Exon Skipping [J].
Bell, Matthew L. ;
Buvoli, Massimo ;
Leinwand, Leslie A. .
MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (08) :1937-1945
[5]   Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].
Cai, XZ ;
Hagedorn, CH ;
Cullen, BR .
RNA, 2004, 10 (12) :1957-1966
[6]   Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways [J].
Cao, Guojun ;
Huang, Baochun ;
Liu, Zhaohui ;
Zhang, Jiyan ;
Xu, Hua ;
Xia, Wei ;
Li, Jie ;
Li, Shaohua ;
Chen, Liucun ;
Ding, Hongmei ;
Zhao, Qiang ;
Fan, Ming ;
Shen, Beifen ;
Shao, Ningsheng .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 396 (04) :978-982
[7]   Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2 [J].
Dill, Holger ;
Linder, Bastian ;
Fehr, Alexander ;
Fischer, Utz .
GENES & DEVELOPMENT, 2012, 26 (01) :25-30
[8]   Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA [J].
Ding, Jie ;
Huang, Shenglin ;
Wu, Shunquan ;
Zhao, Yingjun ;
Liang, Linhui ;
Yan, Mingxia ;
Ge, Chao ;
Yao, Jian ;
Chen, Taoyang ;
Wan, Dafang ;
Wang, Hongyang ;
Gu, Jianren ;
Yao, Ming ;
Li, Jinjun ;
Tu, Hong ;
He, Xianghuo .
NATURE CELL BIOLOGY, 2010, 12 (04) :390-U208
[9]   miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts [J].
Eiring, Anna M. ;
Harb, Jason G. ;
Neviani, Paolo ;
Garton, Christopher ;
Oaks, Joshua J. ;
Spizzo, Riccardo ;
Liu, Shujun ;
Schwind, Sebastian ;
Santhanam, Ramasamy ;
Hickey, Christopher J. ;
Becker, Heiko ;
Chandler, Jason C. ;
Andino, Raul ;
Cortes, Jorge ;
Hokland, Peter ;
Huettner, Claudia S. ;
Bhatia, Ravi ;
Roy, Denis C. ;
Liebhaber, Stephen A. ;
Caligiuri, Michael A. ;
Marcucci, Guido ;
Garzon, Ramiro ;
Croce, Carlo M. ;
Calin, George A. ;
Perrotti, Danilo .
CELL, 2010, 140 (05) :652-665
[10]   A minicircuitry comprised of MicroRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis [J].
Fazi, F ;
Rosa, A ;
Fatica, A ;
Gelmetti, V ;
De Marchis, ML ;
Nervi, C ;
Bozzoni, I .
CELL, 2005, 123 (05) :819-831
123456