A novel and facile synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones via a one-pot multi-component reaction

被引：69
作者：
Heravi, Majid M. [1 ]
Baghernejad, Bita [1 ]
Oskooie, Hossein A. [1 ]
Hekmatshoar, Rahim [1 ]
机构：
[1] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 42期
关键词：
cyclohexyl isocyanide; 1,3-dicarbonyl compound; multi-component reaction; 1H-indole-4(5H)-ones;
D O I：
10.1016/j.tetlet.2008.08.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones was achieved via a one-pot multi-component reaction of cyclohexyl isocyanide, an aldehyde, a 1,3-dicarbonyl compound, and ammonium acetate in the presence of a catalytic amount of KHSO4 in acetonitrile. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6101 / 6103
页数：3
相关论文
共 30 条
  • [1] Adams D. J., 2004, CHEM ALTERNATIVE REA
  • [2] Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO
  • [3] 2-A
  • [4] Catalytic synthesis of aldehydes and ketones under mild conditions using TEMPO/Oxone
    Bolm, C
    Magnus, AS
    Hildebrand, JP
    [J]. ORGANIC LETTERS, 2000, 2 (08) : 1173 - 1175
  • [5] Dax SL, 1999, CURR MED CHEM, V6, P255
  • [6] Dömling A, 2000, CURR OPIN CHEM BIOL, V4, P318, DOI 10.1016/S1367-5931(00)00095-8
  • [7] Recent advances in isocyanide-based multicomponent chemistry
    Dömling, A
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (03) : 306 - 313
  • [8] Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO
  • [9] 2-U
  • [10] KHSO4 supported onto bentonite, A versatile reagent for aromatization of hantzsch 1,4-dihydropyridines
    Heravi, Majid M.
    Bakhtiari, Khadijeh
    Oskooie, Hossein A.
    [J]. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2007, 54 (03) : 579 - 581
123