Fetuin-A: the missing link in lipid-induced inflammation

被引：53

作者：

Heinrichsdorff, Jan ^{[1
]}

Olefsky, Jerrold M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA

来源：

NATURE MEDICINE | 2012年 / 18卷 / 08期

关键词：

INDUCED INSULIN-RESISTANCE; INNATE IMMUNITY; ADIPOSE-TISSUE; FATTY-ACIDS; TLR4;

D O I：

10.1038/nm.2869

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The liver secretory protein fetuin-A (FetA) is now shown to act as an adaptor protein between free fatty acids (FFAs) and Toll-like receptor 4 (TLR4), providing the missing link between FFAs and chronic low-grade inflammation that impairs insulin sensitivity (pages 1279-1285).

引用

页码：1182 / +

页数：31

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