Evaluation of 3D-CRT, IMRT and VMAT radiotherapy plans for left breast cancer based on clinical dosimetric study

被引:49
作者
Liu, Haiyun [1 ]
Chen, Xinde [2 ]
He, Zhijian [2 ]
Li, Jun [3 ]
机构
[1] Jiangxi Univ Tradit Chinese Med, Nanchang 330029, Jiangxi, Peoples R China
[2] Tumor Hosp Jiangxi Prov, Nanchang 330029, Jiangxi, Peoples R China
[3] Jiangsu Subei Peoples Hosp, Yangzhou 225001, Jiangsu, Peoples R China
关键词
Left breast cancer; 3D-CRT; IMRT; VMAT; Dosimetry; VOLUMETRIC MODULATED ARC; THERAPY; IRRADIATION; DELIVERY;
D O I
10.1016/j.compmedimag.2016.10.001
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Objective: This paper aims to compare dosimetric differences based on three types of radiotherapy plans for postoperative left breast cancer. In particular, based on a clinical dosimetric study, the three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiation therapy (IMRT) and VMAT plans were implemented on 15 cases of postoperative patients with left breast cancer with prescription doses of 5000 cGy. Methods and results: Dose volume histogram (DVH) was used to analyze each evaluation index of clinical target volume (CTV) and organs at risk (OARS). Except for homogeneous index (HI), D-2, each cry evaluation index of 3D-CRT plan was inferior to IMRT and VMAT plans (P <0.05). Compared with the VMAT plans, IMRT has a statistical significance only in D-mean, V-95 (P < 0.05). On the contrary, D-mean pertaining to the VMAT plan is much closer to the prescription dose with a V95 coverage rate as high as 97.44%. For the infected lung, V-5, V-10 of 3D-CRT were the lowest (P<0.05), while V-20, V-30 were the highest (P<0.05) among the three types of plans. Here, the V5, V-10 of infected lung were slightly higher (P< 0.05) for the VMAT and IMRT plans. Each evaluation index of the contralateral lung and heart in 3D-CRT was the lowest (P < 0.05). D-1 of contralateral breast was lower in both IMRT and VMAT plans, which were 1770.89 +/- 121.16 cGy and 1839.92 +/- 92.77 cGy, respectively. While D1 of the spinal cord in IMRT and VMAT plans was higher, which were 1990.12 +/- 61.52 cGy and 1927.38 +/- 43.67 cGy, respectively. When the radiation dose of 500-1500 cGy was delivered to the normal tissues, 3D-CRT significantly shows the lowest volume, VMAT is relatively higher. Monitor Units (MU) and treatment time (T) of VMAT were the least, only 49.33% and 55.86% of those of IMRT. Conclusion: The three types of plans can meet the clinical dosimetry demands of postoperative radiotherapy for left breast cancer. The target of IMRT and VMAT plans has a better conformity, and the VMAT plan takes the advantages of less MU and treatment time. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1 / 5
页数:5
相关论文
共 16 条
[1]  
Changsheng Ma, 2010, CHIN J RAD MED PROT, V30, P581
[2]   Radiation-induced pulmonary toxicity: A dose-volume histogram analysis in 201 patients with lung cancer [J].
Hernando, ML ;
Marks, LB ;
Bentel, GC ;
Zhou, SM ;
Hollis, D ;
Das, SK ;
Fan, M ;
Munley, MT ;
Shafman, TD ;
Anscher, MS ;
Lind, PA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (03) :650-659
[3]  
Heyi Fu, 2009, CHIN J RAD ONCOL, V18, P439
[4]   UNACCEPTABLE COSMESIS IN A PROTOCOL INVESTIGATING INTENSITY-MODULATED RADIOTHERAPY WITH ACTIVE BREATHING CONTROL FOR ACCELERATED PARTIAL-BREAST IRRADIATION [J].
Jagsi, Reshma ;
Ben-David, Merav A. ;
Moran, Jean M. ;
Marsh, Robin B. ;
Griffith, Kent A. ;
Hayman, James A. ;
Pierce, Lori J. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 76 (01) :71-78
[5]  
Jinhu Chen, 2010, CHIN J RAD ONCOL, V19, P429
[6]   Radiation pneumonitis as a function of mean lung dose: An analysis of pooled data of 540 patients [J].
Kwa, SLS ;
Lebesque, JV ;
Theuws, JCM ;
Marks, LB ;
Munley, MT ;
Bentel, G ;
Oetzel, D ;
Spahn, U ;
Ten Haken, RK ;
Drzymala, RE ;
Purdy, JA ;
Lichter, AS ;
Martel, MK ;
TEN Haken, RK .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 42 (01) :1-9
[7]  
Li J. B., 2009, CHINESE J ONCOL, V31, P617
[8]  
Menzel H.G., 2010, J ICRU, V10, pNP2, DOI [10.1093/jicru_ndq001, DOI 10.1093/JICRU/NDQ001]
[9]   Volumetric modulated arc therapy: IMRT in a single gantry arc [J].
Otto, Karl .
MEDICAL PHYSICS, 2008, 35 (01) :310-317
[10]   VOLUMETRIC MODULATED ARC THERAPY FOR DELIVERY OF PROSTATE RADIOTHERAPY: COMPARISON WITH INTENSITY-MODULATED RADIOTHERAPY AND THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY [J].
Palma, David ;
Vollans, Emily ;
James, Kerry ;
Nakano, Sandy ;
Moiseenko, Vitali ;
Shaffer, Richard ;
Mckenzie, Michael ;
Morris, James ;
Otto, Karl .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 72 (04) :996-1001