The Photolyase/Cryptochrome Family of Proteins as DNA Repair Enzymes and Transcriptional Repressors

被引：65

作者：

Kavakli, Ibrahim Halil ^{[1
,2
,3
]}

Baris, Ibrahim ^{[2
]}

Tardu, Mehmet ^{[3
]}

Gul, Seref ^{[1
]}

Oner, Hasimcan ^{[1
]}

Cal, Sibel ^{[2
]}

Bulut, Selma ^{[1
]}

Yarparvar, Darya ^{[1
]}

Berkel, Caglar ^{[2
]}

Ustaoglu, Pinar ^{[2
]}

Aydin, Cihan ^{[4
]}

机构：

[1] Koc Univ, Dept Chem & Biol Engn, Istanbul, Turkey

[2] Koc Univ, Dept Mol Biol & Genet, Istanbul, Turkey

[3] Koc Univ, Dept Computat Sci & Engn, Istanbul, Turkey

[4] Istanbul Medeniyet Univ, Dept Mol Biol & Genet, Istanbul, Turkey

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2017年 / 93卷 / 01期

关键词：

CYCLOBUTANE PYRIMIDINE DIMER; PHOTOLYASE STRUCTURE REVEALS; RESONANCE ENERGY-TRANSFER; ELECTRON-TRANSFER; CRYSTAL-STRUCTURE; DYNAMIC DETERMINATION; FEMTOSECOND DYNAMICS; ARABIDOPSIS-THALIANA; FUNCTIONAL-ANALYSIS; ULTRAFAST DYNAMICS;

D O I：

10.1111/php.12669

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Light is a very important environmental factor that governs many cellular responses in organisms. As a consequence, organisms possess different kinds of light-sensing photoreceptors to regulate their physiological variables and adapt to a given habitat. The cryptochrome/photolyase family (CPF) includes photoreceptors that perform different functions in different organisms. Photolyases repair ultraviolet-induced DNA damage by a process known as photoreactivation using photons absorbed from the blue end of the light spectrum. On the other hand, cryptochromes act as blue light circadian photoreceptors in plants and Drosophila to regulate growth and development. In mammals, cryptochromes have light-independent functions and are very important transcriptional regulators that act at the molecular level as negative transcriptional regulators of the circadian clock. In this review, we highlight current knowledge concerning the structural and functional relationships of CPF members.

引用

页码：93 / 103

页数：11

共 83 条

[1] HY4 GENE OF A-THALIANA ENCODES A PROTEIN WITH CHARACTERISTICS OF A BLUE-LIGHT PHOTORECEPTOR [J].