Hidden powers of the mitochondria

被引：25

作者：

Alnemri, ES ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Inst, Philadelphia, PA 19107 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1038/10034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The intermembrane space of mitochondria is home to several potentially lethal proteins, including pro-apoptotic caspases. The observation that caspase-9 moves from mitochondria Into the nucleus on the induction of apoptosis provides this caspase with a possible new role.

引用

页码：E40 / E42

页数：3

共 13 条

[1] Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development [J].

Cecconi, F ;

Alvarez-Bolado, G ;

Meyer, BI ;

Roth, KA ;

Gruss, P .

CELL, 1998, 94 (06) :727-737

[2] Differential requirement for Caspase 9 in apoptotic pathways in vivo [J].

Hakem, R ;

Hakem, A ;

Duncan, GS ;

Henderson, JT ;

Woo, M ;

Soengas, MS ;

Elia, A ;

de la Pompa, JL ;

Kagi, D ;

Khoo, W ;

Potter, J ;

Yoshida, R ;

Kaufman, SA ;

Lowe, SW ;

Penninger, JM ;

Mak, TW .

CELL, 1998, 94 (03) :339-352

[3] Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia [J].

Krajewski, S ;

Krajewska, M ;

Ellerby, LM ;

Welsh, K ;

Xie, ZH ;

Deveraux, QL ;

Salvesen, GS ;

Bredesen, DE ;

Rosenthal, RE ;

Fiskum, G ;

Reed, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) :5752-5757

[4] Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking Caspase 9 [J].

Kuida, K ;

Haydar, TF ;

Kuan, CY ;

Gu, Y ;

Taya, C ;

Karasuyama, H ;

Su, MSS ;

Rakic, P ;

Flavell, RA .

CELL, 1998, 94 (03) :325-337

[5] Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis [J].

Li, HL ;

Zhu, H ;

Xu, CJ ;

Yuan, JY .

CELL, 1998, 94 (04) :491-501

[6] Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade [J].

Li, P ;

Nijhawan, D ;

Budihardjo, I ;

Srinivasula, SM ;

Ahmad, M ;

Alnemri, ES ;

Wang, XD .

CELL, 1997, 91 (04) :479-489

[7] Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors [J].

Luo, X ;

Budihardjo, I ;

Zou, H ;

Slaughter, C ;

Wang, XD .

CELL, 1998, 94 (04) :481-490

[8]

SALEH A, IN PRESS J BIOL CEHM

[9] Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition [J].

Soengas, MS ;

Alarcón, RM ;

Yoshida, H ;

Giaccia, AJ ;

Hakem, R ;

Mak, TW ;

Lowe, SW .

SCIENCE, 1999, 284 (5411) :156-159

[10] Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization [J].

Srinivasula, SM ;

Ahmad, M ;

Fernandes-Alnemri, T ;

Alnemri, ES .

MOLECULAR CELL, 1998, 1 (07) :949-957

← 1 2 →