Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants

被引：11

作者：

Maede, Yoshinobu ^{[1
]}

Ibara, Satoshi ^{[1
]}

Nagasaki, Hiraku ^{[1
]}

Inoue, Takeshi ^{[1
]}

Tokuhisa, Takuya ^{[1
]}

Torikai, Motofumi ^{[1
]}

Ishihara, Chie ^{[1
]}

Matsui, Takako ^{[1
]}

Kodaira, Yuichi ^{[1
]}

机构：

[1] Kagoshima City Hosp, Dept Neonatol, Perinatal Med Ctr, Kagoshima 8928580, Japan

来源：

PEDIATRICS INTERNATIONAL | 2013年 / 55卷 / 06期

关键词：

extremely low-birthweight infants; fluconazole; fungal infections; micafungin; miconazole; prophylaxis; BIRTH-WEIGHT INFANTS; LIPOPEPTIDE ANTIFUNGAL AGENT; SYSTEMIC CANDIDIASIS; RISK-FACTORS; NEONATAL CANDIDIASIS; FK463; PHARMACOKINETICS; ASPERGILLOSIS; ECHINOCANDIN; EPIDEMIOLOGY;

D O I：

10.1111/ped.12157

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BackgroundWe conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low-birthweight infants who were born at a gestational age of less than 26 weeks and weighed less than 1000g. MethodsWith a combination of enteral administration of miconazole (6mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5mg/kg/day and 3mg/kg/day, respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth. ResultsThe prophylaxis was successful in seven of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group. ConclusionMCFG was superior to FLCZ as prophylaxis against fungal infections in extremely low-birthweight infants.

引用

页码：727 / 730

页数：4

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