Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants

被引：11
作者：
Maede, Yoshinobu [1 ]
Ibara, Satoshi [1 ]
Nagasaki, Hiraku [1 ]
Inoue, Takeshi [1 ]
Tokuhisa, Takuya [1 ]
Torikai, Motofumi [1 ]
Ishihara, Chie [1 ]
Matsui, Takako [1 ]
Kodaira, Yuichi [1 ]
机构：
[1] Kagoshima City Hosp, Dept Neonatol, Perinatal Med Ctr, Kagoshima 8928580, Japan
来源：
PEDIATRICS INTERNATIONAL | 2013年 / 55卷 / 06期
关键词：
extremely low-birthweight infants; fluconazole; fungal infections; micafungin; miconazole; prophylaxis; BIRTH-WEIGHT INFANTS; LIPOPEPTIDE ANTIFUNGAL AGENT; SYSTEMIC CANDIDIASIS; RISK-FACTORS; NEONATAL CANDIDIASIS; FK463; PHARMACOKINETICS; ASPERGILLOSIS; ECHINOCANDIN; EPIDEMIOLOGY;
D O I：
10.1111/ped.12157
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
BackgroundWe conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low-birthweight infants who were born at a gestational age of less than 26 weeks and weighed less than 1000g. MethodsWith a combination of enteral administration of miconazole (6mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5mg/kg/day and 3mg/kg/day, respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth. ResultsThe prophylaxis was successful in seven of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group. ConclusionMCFG was superior to FLCZ as prophylaxis against fungal infections in extremely low-birthweight infants.
引用
收藏
页码：727 / 730
页数：4
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