CD8 T Cell Memory to a Viral Pathogen Requires Trans Cosignaling between HVEM and BTLA

被引:51
作者
Flynn, Rachel [1 ,3 ]
Hutchinson, Tarun [1 ]
Murphy, Kenneth M. [2 ]
Ware, Carl F. [4 ]
Croft, Michael [3 ]
Salek-Ardakani, Shahram [1 ,3 ]
机构
[1] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA
[2] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA
[3] La Jolla Inst Allergy & Immunol, Div Immune Regulat, San Diego, CA USA
[4] Sanford Burnham Med Res Inst, Infect & Inflammatory Dis Ctr, Lab Mol Immunol, La Jolla, CA USA
基金
美国国家卫生研究院;
关键词
HERPESVIRUS ENTRY MEDIATOR; TNF SUPERFAMILY MEMBERS; LYMPHOCYTE ATTENUATOR; B-LYMPHOCYTE; VACCINIA VIRUS; FAMILY-MEMBERS; CUTTING EDGE; INHIBITORY RECEPTORS; ACTIVATION; IMMUNITY;
D O I
10.1371/journal.pone.0077991
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Defining the molecular interactions required to program activated CD8 T cells to survive and become memory cells may allow us to understand how to augment anti-viral immunity. HVEM (herpes virus entry mediator) is a member of the tumor necrosis factor receptor (TNFR) family that interacts with ligands in the TNF family, LIGHT and Lymphotoxin-alpha, and in the Ig family, B and T lymphocyte attenuator (BTLA) and CD160. The Ig family members initiate inhibitory signaling when engaged with HVEM, but may also activate survival gene expression. Using a model of vaccinia virus infection, we made the unexpected finding that deficiency in HVEM or BTLA profoundly impaired effector CD8 T cell survival and development of protective immune memory. Mixed adoptive transfer experiments indicated that BTLA expressed in CD8 alpha+ dendritic cells functions as a trans-activating ligand that delivers positive co-signals through HVEM expressed in T cells. Our data demonstrate a critical role of HVEM-BTLA bidirectional cosignaling system in antiviral defenses by driving the differentiation of memory CD8 T cells.
引用
收藏
页数:14
相关论文
共 50 条
[41]   Influence of time and number of antigen encounters on memory CD8 T cell development [J].
Martin, Matthew D. ;
Badovinac, Vladimir P. .
IMMUNOLOGIC RESEARCH, 2014, 59 (1-3) :35-44
[42]   The Initial Draining Lymph Node Primes the Bulk of the CD8 T Cell Response and Influences Memory T Cell Trafficking after a Systemic Viral Infection [J].
Olson, Matthew R. ;
McDermott, Daniel S. ;
Varga, Steven M. .
PLOS PATHOGENS, 2012, 8 (12)
[43]   A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α+ DCs to Promote Long-Term T Cell Responses [J].
Yang, Xuanming ;
Zhang, Xunmin ;
Sun, Yonglian ;
Tu, Tony ;
Fu, May Lynne ;
Miller, Mendy ;
Fu, Yang-Xin .
CELL HOST & MICROBE, 2014, 16 (01) :68-80
[44]   Immunologic considerations for generating memory CD8 T cells through vaccination [J].
Butler, Noah S. ;
Nolz, Jeffrey C. ;
Harty, John T. .
CELLULAR MICROBIOLOGY, 2011, 13 (07) :925-933
[45]   No Requirement of Trans Presentations of IL-15 for Human CD8 T Cell Proliferation [J].
Ota, Naruhisa ;
Takase, Mitsuyo ;
Uchiyama, Hidemi ;
Olsen, Shaun K. ;
Kanagawa, Osami .
JOURNAL OF IMMUNOLOGY, 2010, 185 (10) :6041-6048
[46]   γδT Cells Are Required for CD8+ T Cell Response to Vaccinia Viral Infection [J].
Dai, Rui ;
Huang, Xiaopei ;
Yang, Yiping .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[47]   FOXO3 Regulates the CD8 T Cell Response to a Chronic Viral Infection [J].
Sullivan, Jeremy A. ;
Kim, Eui Ho ;
Plisch, Erin H. ;
Suresh, M. .
JOURNAL OF VIROLOGY, 2012, 86 (17) :9025-9034
[48]   Derivation and Maintenance of Virtual Memory CD8 T Cells [J].
Akue, Adovi D. ;
Lee, June-Yong ;
Jameson, Stephen C. .
JOURNAL OF IMMUNOLOGY, 2012, 188 (06) :2516-2523
[49]   Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis [J].
Haddadi, Siamak ;
Thanthrige-Don, Niroshan ;
Afkhami, Sam ;
Khera, Amandeep ;
Jeyanathan, Mangalakumari ;
Xing, Zhou .
SCIENTIFIC REPORTS, 2017, 7
[50]   Listeria Monocytogenes: A Model Pathogen Continues to Refine Our Knowledge of the CD8 T Cell Response [J].
Qiu, Zhijuan ;
Khairallah, Camille ;
Sheridan, Brian S. .
PATHOGENS, 2018, 7 (02)