The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases

被引：48
作者：
Xu, Xizhen [1 ,2 ]
Li, Rui [1 ,2 ]
Chen, Guangzhi [1 ,2 ]
Hoopes, Samantha L. [3 ]
Zeldin, Darryl C. [3 ]
Wang, Dao Wen [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Inst Hypertens, Wuhan, Peoples R China
[3] NIEHS, Div Intramural Res, NIH, POB 12233, Res Triangle Pk, NC 27709 USA
来源：
ADVANCES IN NUTRITION | 2016年 / 7卷 / 06期
基金：
中国国家自然科学基金;
关键词：
cytochrome P450 (CYP) epoxygenase; epoxyeicosatrienoic acid; soluble epoxide hydrolase; insulin resistance; lipid; obesity; type; 2; diabetes; HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS; REDUCES INSULIN-RESISTANCE; FRUCTOSE-TREATED RATS; INDUCED DIABETIC MICE; CARDIOVASCULAR-DISEASE; VASCULAR DYSFUNCTION; ENDOTHELIAL-CELLS; ADIPOSE-TISSUE; LIVER-DISEASE;
D O I：
10.3945/an.116.012245
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Metabolic diseases are associated with an increased risk of developing cardiovascular disease. The features comprising metabolic diseases include obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hypertension. Recent evidence has emerged showcasing a role for cytochrome P450 epoxygenases, soluble epoxide hydrolase, and epoxyeicosatrienoic acids (EETs) in the development and progression of metabolic diseases. This review discusses the current knowledge related to the modulation of cytochrome P450 epoxygenases and soluble epoxide hydrolase to alter concentrations of biologically active EETs, resulting in effects on insulin resistance, lipid metabolism, obesity, and diabetes. Future areas of research to address current deficiencies in the understanding of these enzymes and their eicosanoid metabolites in various aspects of metabolic diseases are also discussed.
引用
收藏
页码：1122 / 1128
页数：7
相关论文
共 67 条
  • [1] CYP2J2 Targeting to Endothelial Cells Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet by Reprogramming Adipocyte Phenotype
    Abraham, Nader G.
    Sodhi, Komal
    Silvis, Anne M.
    Vanella, Luca
    Favero, Gaia
    Rezzani, Rita
    Lee, Craig
    Zeldin, Darryl C.
    Schwartzman, Michal L.
    [J]. HYPERTENSION, 2014, 64 (06) : 1352 - U413
  • [2] Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
    Anstee, Quentin M.
    Targher, Giovanni
    Day, Christopher P.
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2013, 10 (06) : 330 - 344
  • [3] Epoxyeicosatrienoic Acid Pathway in Human Health and Diseases
    Bellien, Jeremy
    Joannides, Robinson
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2013, 61 (03) : 188 - 196
  • [4] Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue
    Bettaieb, Ahmed
    Nagata, Naoto
    AbouBechara, Daniel
    Chahed, Samah
    Morisseau, Christophe
    Hammock, Bruce D.
    Haj, Fawaz G.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (20) : 14189 - 14199
  • [5] Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications
    Burgess, Angela
    Vanella, Luca
    Bellner, Lars
    Schwartzman, Michal L.
    Abraham, Nader G.
    [J]. PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2012, 97 (1-2) : 1 - 16
  • [6] Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension
    Capdevila, Jorge
    Wang, Wenhui
    [J]. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2013, 22 (02) : 163 - 169
  • [7] CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice
    Chen, Guangzhi
    Xu, Renfan
    Zhang, Shasha
    Wang, Yinna
    Wang, Peihua
    Edin, Matthew L.
    Zeldin, Darryl C.
    Wang, Dao Wen
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2015, 308 (02): : E97 - E110
  • [8] Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice
    Chen, Guangzhi
    Wang, Peihua
    Zhao, Gang
    Xu, Gang
    Gruzdev, Artiom
    Zeldin, Darryl C.
    Wang, Dao Wen
    [J]. PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2011, 96 (1-4) : 63 - 71
  • [9] AMPK activation: a therapeutic target for type 2 diabetes?
    Coughlan, Kimberly A.
    Valentine, Rudy J.
    Ruderman, Neil B.
    Saha, Asish K.
    [J]. DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2014, 7 : 241 - 253
  • [10] Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue
    De Taeye, Bart M.
    Morisseau, Christophe
    Coyle, Julie
    Covington, Joseph W.
    Luria, Ayala
    Yang, Jun
    Murphy, Sheila B.
    Friedman, David B.
    Hammock, Bruce B.
    Vaughan, Douglas E.
    [J]. OBESITY, 2010, 18 (03) : 489 - 498
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