Dabrafenib-induced neutrophilic panniculitis in a child undergoing dual BRAF-MEK inhibitor therapy for glioblastoma multiforme

被引：1

作者：

Young, Trevor K. ^{[1
]}

Gutierrez, Daniel ^{[1
]}

Criscito, Maressa C. ^{[1
]}

Kim, Randie H. ^{[1
]}

Lakdawala, Nikita ^{[1
]}

Oza, Vikash S. ^{[1
]}

机构：

[1] NYU, Grossman Sch Med, Ronald O Perelman Dept Dermatol, 240 38th St,11th Floor, New York, NY 10016 USA

来源：

PEDIATRIC DERMATOLOGY | 2020年 / 37卷 / 06期

关键词：

drug reaction; panniculitis;

D O I：

10.1111/pde.14306

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BRAF inhibitor-induced neutrophilic panniculitis is a rare event that is well-characterized in adults undergoing therapy for metastatic melanoma. To date, there are very few reports of this event in children undergoing BRAF inhibitor therapy for low-grade gliomas, all of which were seen with vemurafenib. We report a case of dabrafenib-induced neutrophilic panniculitis in a 9-year-old girl that manifested within several weeks of initiating dual BRAF-MEK inhibitor therapy for glioblastoma multiforme. This case highlights neutrophilic panniculitis as a side effect of dabrafenib in children and serves as a reminder to consider cutaneous side effects of BRAF inhibitors as they are increasingly used to treat children with primary brain tumors.

引用

页码：1185 / 1186

页数：2

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