Von Hippel Lindau Disease with Colon Adenocarcinoma, Renal Cell Carcinoma and Adrenal Pheochromocytoma

被引：7

作者：

Zinnamosca, Laura ^{[1
]}

Laudisi, Anastasia ^{[2
]}

Petramala, Luigi ^{[1
]}

Marinelli, Cristiano ^{[1
]}

Roselli, Mario ^{[2
]}

Vitolo, Domenico ^{[3
]}

Montesani, Chiara ^{[3
]}

Letizia, Claudio ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Internal Med & Med Special, Dept Unit Secondary Hypertens, Rome, Italy

[2] Univ Roma Tor Vergata, Med Oncol Unit, Dept Internal Med, I-00173 Rome, Italy

[3] Univ Roma La Sapienza, Dept Surg, Rome, Italy

来源：

INTERNAL MEDICINE | 2013年 / 52卷 / 14期

关键词：

VHL; colon adenocarcinoma; pheochromocytoma; clear cell renal carcinoma; CANCER; ALPHA; ANGIOGENESIS; EXPRESSION; PROTEIN;

D O I：

10.2169/internalmedicine.52.8278

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome characterized by the presence of heterogeneous tumors derived from different organs. VHL is caused by germline mutations in the VHL tumor suppressor gene located on chromosome 3p25-26. The loss of functional VHL protein contributes to tumorigenesis. VHL tumors are most frequently derived from the kidneys, adrenal gland, central nervous system, eyes, inner ear, epididymis and pancreas. We herein describe the case of a 64-year-old man carrying the VHL gene mutation affected by simultaneous colon adenocarcinoma, renal clear cell carcinoma and adrenal pheochromocytoma.

引用

页码：1599 / 1603

页数：5

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