Development and Validation of a Computational Simulator for Pediatric Acute Respiratory Distress Syndrome Patients

被引：0

作者：

Saffaran, Sina ^{[1
]}

Das, Anup ^{[1
]}

Hardman, Jonathan G. ^{[2
]}

Yehya, Nadir ^{[3
]}

Bates, Declan G. ^{[1
]}

机构：

[1] Univ Warwick, Sch Engn, Coventry, W Midlands, England

[2] Univ Nottingham, Sch Med, Nottingham, England

[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

来源：

2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2017年

关键词：

MECHANICAL VENTILATION; PHYSIOLOGY SIMULATOR; GAS-EXCHANGE; CHILDREN; ADULTS; MODEL;

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This paper presents the adaptation of an advanced cardiorespiratory model of acute respiratory distress syndrome in adult patients to pediatric pathophysiology. We describe how model equations and parameters were revised to represent the physiological characteristics of pediatric Acute Respiratory Distress Syndrome (ARDS) patients. The adapted model was matched to data from twelve mechanically ventilated patients diagnosed with Pediatric Acute Respiratory Distress Syndrome (PARDS), and was shown to reproduce the available clinical data accurately for all patients. This new model constitutes the first detailed computational simulator specifically tailored to PARDS patients, and can be used as an investigational tool for developing and evaluating novel therapeutic strategies.

引用

页码：1521 / 1524

页数：4

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