Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

被引：28
作者：
Davies, Stephen G. [1 ]
Fletcher, Ai M. [1 ]
Thomson, James E. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 77期
关键词：
ENANTIOSELECTIVE TOTAL-SYNTHESIS; STEREOSELECTIVE TOTAL-SYNTHESIS; GROB-TYPE FRAGMENTATIONS; 1ST TOTAL-SYNTHESIS; BETA-AMINO KETONES; ALDOL REACTIONS; ENANTIOMERICALLY PURE; ALPHA-ALKYLATION; DIASTEREOSELECTIVE SYNTHESIS; CYCLIZATION REACTIONS;
D O I：
10.1039/c3cc45463k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This article covers N-acyl chiral auxiliary-based approaches to the asymmetric synthesis of enantiopure aldehydes and ketones. The use of diastereoisomerically pure N-acyl derivatives of chiral auxiliaries (including chiral Weinreb amide equivalents) and their conversion to the corresponding enantiopure aldehydes and ketones in a single synthetic operation by treatment with a hydride reducing agent or an organometallic reagent, respectively, are highlighted.
引用
收藏
页码：8586 / 8598
页数：13
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