Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

被引：7

作者：

Leung, Yvonne ^{[1
]}

Barzilai, Nir ^{[2
]}

Batko-Szwaczka, Agnieszka ^{[3
]}

Beker, Nina ^{[4
]}

Boerner, Kathrin ^{[5
]}

Brayne, Carol ^{[6
]}

Brodaty, Henry ^{[1
]}

Cheung, Karen Siu-Lan ^{[7
]}

Corrada, Maria M. ^{[8
]}

Crawford, John D. ^{[1
]}

Galbussera, Alessia A. ^{[9
]}

Gondo, Yasuyuki ^{[10
]}

Holstege, Henne ^{[11
]}

Hulsman, Marc ^{[11
]}

Ishioka, Yoshiko Lily ^{[12
]}

Jopp, Daniela ^{[13
]}

Kawas, Claudia H. ^{[8
]}

Kaye, Jeff ^{[14
]}

Kochan, Nicole A. ^{[1
]}

Lau, Bobo Hi-Po ^{[15
]}

Lipnicki, Darren M. ^{[1
]}

Lo, Jessica W. ^{[1
]}

Lucca, Ugo ^{[9
]}

Makkar, Steve R. ^{[1
]}

Marcon, Gabriella ^{[16
,17
]}

Martin, Peter ^{[18
]}

Meguro, Kenichi ^{[19
]}

Milman, Sofiya ^{[2
]}

Poon, Leonard W. ^{[20
]}

Recchia, Angela ^{[9
]}

Ribeiro, Oscar ^{[21
,22
]}

Riva, Emma ^{[9
]}

Rott, Christoph ^{[23
]}

Sikkes, Sietske Am ^{[4
,24
]}

Skoog, Ingmar ^{[25
]}

Stephan, Blossom ^{[26
,27
]}

Szewieczek, Jan ^{[3
]}

Teixeira, Laetitia ^{[21
,22
]}

Tettamanti, Mauro ^{[28
]}

Wilczynski, Krzysztof ^{[3
]}

Sachdev, Perminder ^{[1
]}

机构：

[1] Univ New South Wales UNSW, Ctr Hlth Brain Ageing CHeBA, Sch Psychiat, Sydney, NSW, Australia

[2] Albert Einstein Coll Med, New York, NY USA

[3] Med Univ Silesia, Sch Hlth Sci Katowice, Dept Geriatr, Katowice, Poland

[4] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[5] Univ Massachusetts, McCormack Grad Sch, Dept Gerontol, Boston, MA USA

[6] Univ Cambridge, Cambridge, England

[7] Univ Hong Kong HKU, Hong Kong, Peoples R China

[8] Univ Calif Irvine, Irvine, CA USA

[9] Ist Ric Farmacol Mario Negri IRCCS, Lab Geriatr Neuropsychiat, Dept Neurosci, Milan, Italy

[10] Osaka Univ, Grad Sch Human Sci, Sch Human Sci, Osaka, Osaka, Japan

[11] Vrije Univ Amsterdam, Amsterdam UMC Locat VUmc, Human Genet, Genom Neurodegenerat Dis & Aging, Amsterdam, Netherlands

[12] OP Jindal Global Univ, Sonipat, India

[13] Univ Lausanne, Lausanne, Switzerland

[14] Oregon Hlth & Sci Univ, NIA sLayton Aging & Alzheimers Dis Res Ctr, Portland, OR USA

[15] Hong Kong Shue Yan Univ HKSYU, Hong Kong, Peoples R China

[16] Univ Trieste, Trieste, Italy

[17] Univ Udine, Udine, Italy

[18] Iowa State Univ, Ames, IA USA

[19] Tohoku Univ, Geriatr Behav Neurol, Sendai, Miyagi, Japan

[20] Univ Georgia, Athens, GA USA

[21] Univ Aveiro, Ctr Hlth Technol & Serv Res CINTESIS, Porto, Portugal

[22] Univ Porto, ICBAS, Porto, Portugal

[23] Heidelberg Univ, Inst Gerontol, Heidelberg, Germany

[24] Vrije Univ Amsterdam, Sect Clin Neuro & Dev Psychol, Amsterdam, Netherlands

[25] Univ Gothenburg, Gothenburg, Sweden

[26] Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England

[27] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England

[28] Mario Negri Inst Pharmacol Res, Milan, Italy

来源：

ALZHEIMERS & DEMENTIA | 2022年

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

centenarians; dementia; education; exceptional longevity; prevalence; risk factors; MINI-MENTAL-STATE; OLDEST-OLD; BLOOD-PRESSURE; DISEASE; POPULATION; DECLINE; AGE; HEALTH; JAPAN; RATES;

D O I：

10.1002/alz.12828

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionThere are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. MethodsParticipant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals >= 95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. ResultsThe mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92-0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35-0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). DiscussionAmong the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

引用

页码：2265 / 2275

页数：11

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