Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations

被引：43

作者：

Lu, M

Battinelli, L

Daniele, C

Melchioni, C

Salvatore, G

Mazzanti, G

机构：

[1] Univ Roma La Sapienza, Dipartimento Farmacol Sostanze Nat & Fisiol Gen, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[3] Ist Super Sanita, Dept Comparat Toxicol & Ecotoxicol, I-00161 Rome, Italy

来源：

PLANTA MEDICA | 2002年 / 68卷 / 03期

关键词：

Hyssopus officinalis L; Lamiaceae; essential oil; isopinocamphone; muscle relaxing activity;

D O I：

10.1055/s-2002-23139

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The muscle relaxing activity of the essential oil of Hyssopus officinalis L. (Lamiaceae) and some of its main components (isopinocamphone, limonene and beta-pinene) was studied on isolated preparations of guinea-pig and rabbit intestine. The essential oil and isopinocamphone inhibited the acetylcholine- and BaCl2-induced contractions in guinea-pig ileum in a concentration-dependent manner (IC50 42.4 mug/ml and 61.9 mug/ml to acetylcholine; 48.3 mug/ml and 70.4 mug/ml to BaCl2) whereas limonene or beta-pinene left tissue contraction unchanged. In guinea-pig ileum H. officinalis essential oil also blocked the contractions induced by CaCl2. In isolated rabbit jejunum the essential oil reduced the amplitude of spontaneous movements and decreased the basal tone; neither haemoglobin, methylene blue, N-omega-nitro-L-arginine methyl ester (L-NAME) or propranolol blocked the myorelaxant effect.

引用

页码：213 / 216

页数：4

共 28 条

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