Palladium-mediated carbosubstitutions in spiranes

被引：14

作者：

Falck-Pedersen, ML ^{[1
]}

Romming, C ^{[1
]}

Undheim, K ^{[1
]}

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

TETRAHEDRON | 1999年 / 55卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(99)00470-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carbosubstitutions in spirene triflates can be effected by Pd-catalyzed couplings with stannylated or zincated arenes. Differential carbosubstitution resulted from stepwise triflation and coupling in spiro[4,4]nonane-1,6-dione. Catalytic hydrogenation of the 1,6-diphenyl-1,6-diene gave the cic, cis-disubstituted spirane. Metal hydride reduction of intermediate monoketone gave mainly the cis-alcohol. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8525 / 8538

页数：14

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