One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles

被引：5

作者：

Sterligov, Grigorii K. ^{[1
]}

Ageshina, Alexandra A. ^{[1
]}

Rzhevskiy, Sergey A. ^{[1
]}

Shurupova, Olga V. ^{[1
]}

Topchiy, Maxim A. ^{[1
]}

Minaeva, Lidiya I. ^{[1
]}

Asachenko, Andrey F. ^{[1
]}

机构：

[1] Russian Acad Sci, A V Topchiev Inst Petrochem Synth, Moscow 119991, Russia

来源：

ACS OMEGA | 2022年

关键词：

CATALYZED DIRECT CYANATION; MULTISUBSTITUTED INDOLES; BIOLOGICAL EVALUATION; PYRIDINYL-PROPENONES; PYRROLES; AMINE; SUBSTITUTIONS;

D O I：

10.1021/acsomega.2c03754

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corre-sponding N-(o-tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably substituted indoles in good yields from readily available starting materials.

引用

页码：38505 / 38511

页数：7

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