One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles

被引：27

作者：

Frutos, Rogelio P. ^{[1
]}

Wei, Xudong ^{[1
]}

Patel, Nitinchandra D. ^{[1
]}

Tampone, Thomas G. ^{[1
]}

Mulder, Jason A. ^{[1
]}

Busacca, Carl A. ^{[1
]}

Senanayake, Chris H. ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Chem Dev US, Ridgefield, CT 06877 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 11期

关键词：

DIELS-ALDER REACTIONS; STEP SYNTHESIS; AMIDINES; DERIVATIVES; SALTS;

D O I：

10.1021/jo400720p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical, one-step process for the synthesis of 2,5-disubstituted pyrimidines is presented. The protocol proved to be general for the synthesis of a variety of pyrimidine-containing compounds bearing an assortment of functional groups.

引用

页码：5800 / 5803

页数：4

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