Identification of miRNA-miRNA synergistic relationships in colorectal cancer

被引：19
作者：
Zhao, Xuhai [1 ]
Song, Hongjiang [2 ]
Zuo, Zhigui [3 ]
Zhu, Yu [4 ]
Dong, Xinshu [5 ]
Lu, Xiangshi [1 ]
机构：
[1] Harbin Med Univ, Dept Breast Surg, Tumor Hosp, Haerbin, Peoples R China
[2] Harbin Med Univ, Dept Gastrointestinal Surg, Tumor Hosp, Haerbin, Peoples R China
[3] Wenzhou Med Coll, Dept Colorectal Surg, Affiliated Hosp 1, Wenzhou, Peoples R China
[4] Harbin Med Univ, Dept Pharm, Clin Med Coll 4, Haerbin, Peoples R China
[5] Harbin Med Univ, Dept Surg Oncol, Affiliated Clin Med Coll 4, Haerbin, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 55卷
关键词：
Colorectal cancer; MicroRNAs; Synergistic relationships; Functional module; TUMOR-SUPPRESSOR; COLON-CANCER; MICRORNA; GENE; EXPRESSION;
D O I：
10.1016/j.ijbiomac.2012.12.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purpose: A large list of microRNAs (miRNAs) which may play important roles in the tumorigenesis of colorectal cancer (CRC) were generated recently. The purpose of our study is to analyze the synergistic regulations among miRNAs which were differentially expressed in tumorigenesis of CRC. Methods: In this study, we downloaded the miRNA microarray and gene expression microarray of CRC from Gene Expression Omnibus (GEO), and identified the differentially expressed miRNAs (DE-miRNAs) and genes (DEGs) in cancer tissues compared with normal controls. In addition, we investigated the complex synergistic relationships among DE-miRNAs and constructed a miRNA-miRNA synergistic network by assembling all synergistic pairs. Results: A total of 32 DE-miRNAs formed 8 functional modules in the synergistic network. These miRNAs in functional modules could independently implement specific functions as a whole in CRC, such as endocytosis, cell cycle, and p53 signaling pathway. Conclusions: The network allows for an in-depth analysis of individual miRNAs in the context of their synergistic surroundings. (C) 2012 Elsevier B.V. All rights reserved.
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收藏
页码：98 / 103
页数：6
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