Disruption of the SLC26A3-mediated anion transport is associated with male subfertility

被引：35
作者：
Höglund, P
Hihnala, S
Kujala, M
Tiitinen, A
Dunkel, L
Holmberg, C
机构：
[1] Univ Helsinki, Dept Pediat, Hosp Children & Adolescents, Helsinki 00029, Finland
[2] Univ Helsinki, Dept Med Genet, Helsinki, Finland
[3] Univ Helsinki, Cent Hosp, Dept Urol, Helsinki, Finland
[4] Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, Helsinki, Finland
[5] Kuopio Univ Hosp, Dept Pediat, SF-70210 Kuopio, Finland
来源：
FERTILITY AND STERILITY | 2006年 / 85卷 / 01期
关键词：
D O I：
10.1016/j.fertnstert.2005.06.043
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Male subfertility in congenital chloride diarrhea (CLD) was possible after identification of expression of an epithelial Cl-/HCO3-exchanger SLC26A3 in the male reproductive tract and by the observation that adult men with CLD had very few children. A prospective clinical and laboratory study among eight adult Finnish men with CLD revealed constant oligoasthenoteratozoospermia but normal spermatogenesis, high chloride and low pH in seminal plasma, and three spermatoceles, suggesting that male subfertility is a clinical manifestation of CLD and could be caused by an analogous defect in the epithelial Cl-/HCO3- and water transport, as described for the CLD intestine.
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页码：232 / 235
页数：4
相关论文
共 27 条
[1]   Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis [J].
Choi, JY ;
Muallem, D ;
Kiselyov, K ;
Lee, MG ;
Thomas, PJ ;
Muallem, S .
NATURE, 2001, 410 (6824) :94-97
[2]  
Clulow J, 1998, J REPROD FERTIL, P1
[3]   Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cells [J].
Greeley, T ;
Shumaker, H ;
Wang, ZH ;
Schweinfest, CW ;
Soleimani, M .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 281 (05) :G1301-G1308
[4]   The congenital chloride diarrhea gene is expressed in seminal vesicle, sweat gland, inflammatory colon epithelium, and in some dysplastic colon cells [J].
Haila, S ;
Saarialho-Kere, U ;
Karjalainen-Lindsberg, ML ;
Lohi, H ;
Airola, K ;
Holmberg, C ;
Hästbacka, J ;
Kere, J ;
Höglund, P .
HISTOCHEMISTRY AND CELL BIOLOGY, 2000, 113 (04) :279-286
[5]   Estrogen in the adult male reproductive tract: A review [J].
Rex A Hess .
Reproductive Biology and Endocrinology, 1 (1)
[6]   Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea [J].
Hoglund, P ;
Haila, S ;
Socha, J ;
Tomaszewski, L ;
SaarialhoKere, U ;
KarjalainenLindsberg, ML ;
Airola, K ;
Holmberg, C ;
delaChapelle, A ;
Kere, J .
NATURE GENETICS, 1996, 14 (03) :316-319
[7]   Distinct outcomes of chloride diarrhoea in two siblings with identical genetic background of the disease:: implications for early diagnosis and treatment [J].
Höglund, P ;
Holmberg, C ;
Sherman, P ;
Kere, J .
GUT, 2001, 48 (05) :724-727
[8]   Genetic background of congenital chloride diarrhea in high-incidence populations:: Finland, Poland, and Saudi Arabia and Kuwait [J].
Höglund, P ;
Auranen, M ;
Socha, J ;
Popinska, K ;
Nazer, H ;
Rajaram, U ;
Al Sanie, A ;
Al-Ghanim, M ;
Holmberg, C ;
de la Chapelle, A ;
Kere, J .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (03) :760-768
[9]   COLONIC ELECTROLYTE TRANSPORT IN HEALTH AND IN CONGENITAL CHLORIDE DIARRHEA [J].
HOLMBERG, C ;
PERHEENTUPA, J ;
LAUNIALA, K .
JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (02) :302-310
[10]  
HOLMBERG C, 1986, CLIN GASTROENTEROL, V15, P583
123