Eluxadoline: First Global Approval

被引：30

作者：

Garnock-Jones, Karly P. ^{[1
]}

机构：

[1] Springer, Auckland 0754, New Zealand

来源：

DRUGS | 2015年 / 75卷 / 11期

关键词：

IRRITABLE-BOWEL-SYNDROME;

D O I：

10.1007/s40265-015-0436-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eluxadoline (Viberzi (TM)), developed by Actavis (now Allergan), is an orally administered, first-in-class compound that functions as both a l-opioid receptor agonist and a delta-opioid receptor antagonist, and is indicated for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D) in adults. The agent was originally developed by Janssen Pharmaceutica. Eluxadoline has been approved in the US, and submissions to other global authorities are being contemplated or planned. This article summarizes the milestones in the development of eluxadoline leading to this first approval for IBS-D.

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收藏

页码：1305 / 1310

页数：6

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