Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications

被引：9
|
作者：
Oh, Seung-Ick [1 ]
Lee, Chang Kyu [1 ]
Cho, Kyung Jin [1 ]
Lee, Kyung-Ok [2 ]
Cho, Ssang-Goo [3 ,4 ]
Hong, Sunghoi [1 ]
机构：
[1] Korea Univ, Dept Biomed Sci, Coll Hlth Sci, Seoul 136703, South Korea
[2] NeoDIN Med Inst, Div Stem Cell Res, Seoul 133847, South Korea
[3] Konkuk Univ, Dept Anim Biotechnol, Seoul 143701, South Korea
[4] Konkuk Univ, Anim Resources Res Ctr, Seoul 143701, South Korea
来源：
SCIENTIFIC WORLD JOURNAL | 2012年
基金：
新加坡国家研究基金会;
关键词：
HUMAN SOMATIC-CELLS; EPSTEIN-BARR-VIRUS; STABLE REPLICATION; DEFINED FACTORS; MOUSE; INDUCTION; VECTOR; ADULT; OCT4; DIFFERENTIATION;
D O I：
10.1100/2012/417809
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.
引用
收藏
页数：10
相关论文
共 50 条
  • [1] Recent technological updates and clinical applications of induced pluripotent stem cells
    Diecke, Sebastian
    Jung, Seung Min
    Lee, Jaecheol
    Ju, Ji Hyeon
    KOREAN JOURNAL OF INTERNAL MEDICINE, 2014, 29 (05) : 547 - 557
  • [2] Experimental approaches for the generation of induced pluripotent stem cells
    Sommer, Cesar A.
    Mostoslavsky, Gustavo
    STEM CELL RESEARCH & THERAPY, 2010, 1
  • [3] The Progress of Induced Pluripotent Stem Cells (iPSCs) for Research and Applications
    Fu Yu-Hua
    Zhou Xiu-Mei
    Xu Feng-Qing
    Qian Qi-Jun
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2011, 38 (02) : 101 - 112
  • [4] Efficient Generation of Nonhuman Primate Induced Pluripotent Stem Cells
    Zhong, Bonan
    Trobridge, Grant D.
    Zhang, Xiaobing
    Watts, Korashon L.
    Ramakrishnan, Aravind
    Wohlfahrt, Martin
    Adair, Jennifer E.
    Kiem, Hans-Peter
    STEM CELLS AND DEVELOPMENT, 2011, 20 (05) : 795 - 807
  • [5] Progress and Promise Towards Safe Induced Pluripotent Stem Cells for Therapy
    Seifinejad, Ali
    Tabebordbar, Mohammadsharif
    Baharvand, Hossein
    Boyer, Laurie A.
    Salekdeh, Ghasem Hosseini
    STEM CELL REVIEWS AND REPORTS, 2010, 6 (02) : 297 - 306
  • [6] Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells
    Yoshida, Yoshinori
    Takahashi, Kazutoshi
    Okita, Keisuke
    Ichisaka, Tomoko
    Yamanaka, Shinya
    CELL STEM CELL, 2009, 5 (03) : 237 - 241
  • [7] Generation of Induced Pluripotent Stem Cells from Somatic Cells
    Sohn, Young-Doug
    Han, Ji Woong
    Yoon, Young-sup
    GENETICS OF STEM CELLS, PT A, 2012, 111 : 1 - 26
  • [8] Generation of Mouse Induced Pluripotent Stem Cells by Protein Transduction
    Nemes, Csilla
    Varga, Eszter
    Polgar, Zsuzsanna
    Klincumhom, Nuttha
    Pirity, Melinda K.
    Dinnyes, Andras
    TISSUE ENGINEERING PART C-METHODS, 2014, 20 (05) : 383 - 392
  • [9] Clinical Applications of Induced Pluripotent Stem Cells - Stato Attuale
    Kavyasudha, Chavali
    Macrin, Dannie
    ArulJothi, K. N.
    Joseph, Joel P.
    Harishankar, M. K.
    Devi, Arikketh
    CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 1: STEM CELLS IN REGENERATIVE MEDICINE: ADVANCES AND CHALLENGES, 2018, 1079 : 127 - 149
  • [10] Human induced pluripotent stem cells-from mechanisms to clinical applications
    Drews, Katharina
    Jozefczuk, Justyna
    Prigione, Alessandro
    Adjaye, James
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2012, 90 (07): : 735 - 745
12345