Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer

被引:3
作者
Saptari, V
Youcef-Toumi, K
机构
[1] Delta Search Labs, Cambridge, MA 02139 USA
[2] MIT, Cambridge, MA 02139 USA
关键词
noninvasive; diabetes; spectroscopy; sensitivity; selectivity;
D O I
10.1117/1.2141934
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Near- infrared measurements of glucose in human plasma are performed using a custom, rapid, high- throughput filter- based spectrometer covering a spectral range between 2080 and 2315 nm. Quality of the measured glucose signals is quantified through the use of two figures of merit: selectivity and limit of detection. Selectivity measures the uniqueness of the glucose spectrum from among the interfering spectra. Limit of detection measures the smallest glucose concentration change detectable. The proposed system, which includes the spectroscopic hardware and a spectral preprocessing algorithm, is shown to produce a selectivity value of 0.57, with zero being nonselective and one being fully selective, and a limit of detection value of 2.2 mM. Prediction of an independent dataset is also performed using net analyte signal- based and partial least- squares multivariate calibration techniques, which produce standard error of prediction values of 1.14 and 1.45 mM, respectively. (C) 2005 Society of Photo-Optical Instrumentation Engineers.
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页数:9
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共 26 条
[1]   DETERMINATION OF PHYSIOLOGICAL LEVELS OF GLUCOSE IN AN AQUEOUS MATRIX WITH DIGITALLY FILTERED FOURIER-TRANSFORM NEAR-INFRARED SPECTRA [J].
ARNOLD, MA ;
SMALL, GW .
ANALYTICAL CHEMISTRY, 1990, 62 (14) :1457-1464
[2]   An enhanced algorithm for linear multivariate calibration [J].
Berger, AJ ;
Koo, TW ;
Itzkan, I ;
Feld, MS .
ANALYTICAL CHEMISTRY, 1998, 70 (03) :623-627
[3]   Multivariate detection limits estimators [J].
Boque, R ;
Rius, FX .
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 1996, 32 (01) :11-23
[4]   Sources of absorption and scattering contrast for near-infrared optical mammography [J].
Cerussi, AE ;
Berger, AJ ;
Bevilacqua, F ;
Shah, N ;
Jakubowski, D ;
Butler, J ;
Holcombe, RF ;
Tromberg, BJ .
ACADEMIC RADIOLOGY, 2001, 8 (03) :211-218
[5]   Determination of glucose in a synthetic biological matrix with decimated time-domain filtered near-infrared interferogram data [J].
Cingo, NA ;
Small, GW ;
Arnold, MA .
VIBRATIONAL SPECTROSCOPY, 2000, 23 (01) :103-117
[6]   Figures of merit in multivariate calibration. Determination of four pesticides in water by flow injection analysis and spectrophotometric detection [J].
Ferre, J ;
Boque, R ;
FernandezBand, B ;
Larrechi, MS ;
Rius, FX .
ANALYTICA CHIMICA ACTA, 1997, 348 (1-3) :167-175
[7]   Net analyte signal calculation for multivariate calibration [J].
Ferré, J ;
Faber, NM .
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2003, 69 (1-2) :123-136
[8]   Enhancing calibration models for non-invasive near-infrared spectroscopical blood glucose determination [J].
Fischbacher, C ;
Jagemann, KU ;
Danzer, K ;
Muller, UA ;
Papenkordt, L ;
Schuler, J .
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 1997, 359 (01) :78-82
[9]   PARTIAL LEAST-SQUARES METHODS FOR SPECTRAL ANALYSES .1. RELATION TO OTHER QUANTITATIVE CALIBRATION METHODS AND THE EXTRACTION OF QUALITATIVE INFORMATION [J].
HAALAND, DM ;
THOMAS, EV .
ANALYTICAL CHEMISTRY, 1988, 60 (11) :1193-1202
[10]   Multivariate determination of glucose concentrations from optimally filtered frequency-warped NIR spectra of human blood serum [J].
Ham, FM ;
Cohen, GM ;
Kostanic, I ;
Gooch, BR .
PHYSIOLOGICAL MEASUREMENT, 1996, 17 (01) :1-20