The art and design of genetic screens: Zebrafish

被引：333
作者：
Patton, EE [1 ]
Zon, LI [1 ]
机构：
[1] Childrens Hosp Boston, Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
NATURE REVIEWS GENETICS | 2001年 / 2卷 / 12期
关键词：
D O I：
10.1038/35103567
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Inventive. genetic screens in zebrafish are revealing:, new genetic pathways that control, vertebrate development, disease and behaviour. By exploiting the versatility of zebrafish,, biological processes that had been previously obscured can be visualized and many of the responsible genes can be isolated. Coupled! with gene knockdown and overexpression technologies, and small-molecule-induced phenotypes, genetic screens in zebrafish provide a powerful system by which to dissect vertebrate gene function and gene networks.
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收藏
页码：956 / 966
页数：11
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