Refining endpoints in brain tumor clinical trials

被引：36
|
作者：
Meyers, Christina A. [1 ]
Rock, Edwin P. [2 ]
Fine, Howard A. [3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA
[2] Otsuka Pharmaceut Dev & Commercializat Inc, Rockville, MD USA
[3] NCI, Neurooncol Branch, Bethesda, MD 20892 USA
来源：
JOURNAL OF NEURO-ONCOLOGY | 2012年 / 108卷 / 02期
关键词：
Brain cancer; Clinical trials; Neurocognitive function; NEUROCOGNITIVE FUNCTION; COGNITIVE FUNCTION; PROGRESSION; RADIATION; CANCER; GLIOMA;
D O I：
10.1007/s11060-012-0813-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
As targeted therapies advance treatment for brain tumors, standard clinical trial endpoints of survival, progression free survival and radiographic response have become insufficient to capture clinical benefit. Brain cancer is a malignancy with neurodegenerative features. In this setting prolongation of life and/or radiographic stability are less clinically meaningful if neurocognitive function substantially declines. Hence evaluation of new therapeutic strategies should routinely include periodic assessment of neurocognitive function.
引用
收藏
页码：227 / 230
页数：4
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