Highly Branched Poly(β-Amino Esters): Synthesis and Application in Gene Delivery

被引：89

作者：

Cutlar, Lara ^{[1
]}

Zhou, Dezhong ^{[1
]}

Gao, Yongsheng ^{[1
]}

Zhao, Tianyu ^{[1
]}

Greiser, Udo ^{[1
]}

Wang, Wei ^{[1
,2
]}

Wang, Wenxin ^{[1
,2
]}

机构：

[1] Univ Coll Dublin, Charles Inst Dermatol, Sch Med & Med Sci, Dublin 4, Ireland

[2] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China

来源：

BIOMACROMOLECULES | 2015年 / 16卷 / 09期

基金：

爱尔兰科学基金会;

关键词：

POLYMER LIBRARY APPROACH; IN-VIVO; TRANSGENE EXPRESSION; MOLECULAR-WEIGHT; MINICIRCLE DNA; PLASMID DNA; THERAPY; TRANSFECTION; CHITOSAN; CARRIERS;

D O I：

10.1021/acs.biomac.5b00966

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Highly branched poly(beta-amino esters) (HPAEs) are developed via a facile and controllable "A2+B3/B2" strategy successfully. As nonviral gene delivery vectors, the performance of HPAEs is superior to the well-studied linear counterpart as well as the leading commercial reagent Superfect. When combined with minicircle DNA construct, HPAEs can achieve ultrahigh gene transfection efficiency, especially in keratinocytes.

引用

页码：2609 / 2617

页数：9

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