A New Approach to Highly Substituted Cyclopentanoids from a Concise Formal Synthesis of (+)-Roseophilin

被引：26

作者：

Kerr, Daniel J. ^{[1
]}

Flynn, Bernard L. ^{[1
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 07期

基金：

澳大利亚研究理事会;

关键词：

NAZAROV CYCLIZATION; ASYMMETRIC-SYNTHESIS; TRICYCLIC CORE; BRONSTED ACID; ROSEOPHILIN; CYCLOPENTENONES;

D O I：

10.1021/ol300332b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent reaction sequence involving a reductive coupling and a chiral Bronsted acid catalyzed Nazarov reaction is utilized in a concise formal synthesis of (+)-roseophilin (11 steps via longest linear sequence, 10.2% yield, 95% ee).

引用

页码：1740 / 1743

页数：4

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