New insights into the pathogenesis ofStreptococcus pneumoniae-associated hemolytic uremic syndrome

被引：24

作者：

Scobell, Rebecca R. ^{[1
]}

Kaplan, Bernard S. ^{[1
]}

Copelovitch, Lawrence ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Pediat, Div Nephrol, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA

来源：

PEDIATRIC NEPHROLOGY | 2020年 / 35卷 / 09期

关键词：

P-HUS; Alternative complement pathway; Eculizumab; Plasmapheresis; THOMSEN-FRIEDENREICH ANTIGEN; STREPTOCOCCUS-PNEUMONIAE; T-ACTIVATION; CONJUGATED HYPERBILIRUBINEMIA; PNEUMOCOCCAL NEURAMINIDASE; SIALIC-ACID; FACTOR-H; COMPLEMENT; GALECTIN-3; DISEASE;

D O I：

10.1007/s00467-019-04342-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The purpose of this review is to describeStreptococcus pneumoniae-associated hemolytic uremic syndrome (P-HUS) with emphasis on new insights into the pathophysiology and management over the past 10 years. Even though awareness of this clinico-pathological entity has increased, it likely remains under-recognized. Recent observations indicate that although neuraminidase activity and exposure of the T-antigen are necessary for development of P-HUS, they are not sufficient; activation of the alternate pathway of complement may also contribute. It is unclear, however, whether or not eculizumab and/or plasmapheresis are of value.

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收藏

页码：1585 / 1591

页数：7

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