Further terpenoids from Euphorbia tirucalli

被引：31

作者：

Thuc-Huy Duong ^{[1
,2
]}

Beniddir, Mehdi A. ^{[3
]}

Genta-Jouve, Gregory ^{[4
]}

Huu-Hung Nguyen ^{[5
]}

Dinh-Phuoc Nguyen ^{[6
]}

Thi-Anh-Tuyet Nguyen ^{[7
]}

Dinh-Hung Mac ^{[8
]}

Boustie, Joel ^{[9
]}

Kim-Phi-Phung Nguyen ^{[10
]}

Chavasiri, Warinthorn ^{[6
]}

Le Pogam, Pierre ^{[3
]}

机构：

[1] Ton Duc Thang Univ, Dept Management Sci & Technol Dev, Ho Chi Minh City, Vietnam

[2] Ton Duc Thang Univ, Fac Sci Appl, Ho Chi Minh City, Vietnam

[3] Univ Paris Saclay, Univ Paris Sud, BioCIS, CNRS, 5 Rue JB Clement, F-92290 Chatenay Malabry, France

[4] Univ Paris 05, Equipe C TAC, UMR CNRS 8638, COMETE, 4 Ave Observ, F-75006 Paris, France

[5] Nguyen Tat Thanh Univ, Fac Hitech Agr & Biotechnol, 300A Nguyen Tat Thanh Str,Dist 4, Ho Chi Minh City 748355, Vietnam

[6] Chulalongkorn Univ, Fac Sci, Dept Chem, Phayathai Rd, Bangkok 10330, Thailand

[7] Ho Chi Minh City Univ Educ, Dept Chem, 280 An Duong Vuong St,Dist 5, Ho Chi Minh City 748342, Vietnam

[8] Ha Noi Natl Univ, Univ Sci, Nat Prod Res Unit, Dept Organ Chem, 19 Le Thanh Tong Str, Hanoi 748355, Vietnam

[9] Univ Rennes, CNRS, ISCR, UMR 6226, F-35000 Rennes, France

[10] Natl Univ, Univ Sci, Dept Organ Chem, 227 Nguyen Van Cu Str,Dist 5, Ho Chi Minh City 748355, Vietnam

来源：

FITOTERAPIA | 2019年 / 135卷

关键词：

Euphorbia tirucalli L; Euphorbiaceae; Sesquiterpene; Cadalene; Triterpenes; Tirucallane; Euphane; CYCLOARTANE-TYPE TRITERPENES; CADINANE SESQUITERPENOIDS; MEDICINAL FLOWERS; PLANT-EXTRACTS; CONSTITUENTS; EUPHANE; ALCOHOL; ACTIVATION; PEROXIDE; ROOTS;

D O I：

10.1016/j.fitote.2019.04.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C-13) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. All these compounds were tested for cytotoxicity against K562, MCF-7 and/or and HepG2 tumor cell lines. Only tirucadalenone displayed a mild cytotoxic activity.

引用

页码：44 / 51

页数：8

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